Description
Description:
Afinitor is a medication manufactured by Novartis India Ltd. containing the active ingredient Everolimus. It is available in tablet form with a strength of 10 mg and is typically supplied in a pack of 30 tablets. Everolimus is a prescription medication belonging to a class of drugs known as mammalian target of rapamycin (mTOR) inhibitors.
Indications:
Afinitor (Everolimus) is indicated for the treatment of various types of cancer and non-cancerous conditions:
- Cancer Treatment:
- Afinitor is approved for use in the treatment of several types of cancer, including:
- Advanced renal cell carcinoma (kidney cancer) after failure of treatment with other agents.
- Hormone receptor-positive, HER2-negative advanced breast cancer in postmenopausal women, in combination with exemestane, after failure of treatment with other hormonal therapies.
- Neuroendocrine tumors of pancreatic, gastrointestinal, or lung origin that are unresectable, locally advanced, or metastatic.
- Afinitor is approved for use in the treatment of several types of cancer, including:
- Non-Cancerous Conditions:
- Afinitor is also used to treat non-cancerous conditions such as tuberous sclerosis complex (TSC) with subependymal giant cell astrocytoma (SEGA) in adults and pediatric patients who require therapy but are not candidates for surgical resection.
Mechanism of Action:
Everolimus works by inhibiting the mammalian target of rapamycin (mTOR) pathway, which plays a key role in regulating cell growth, proliferation, and angiogenesis (formation of new blood vessels). By blocking this pathway, Everolimus slows down the growth and spread of cancer cells and reduces the size of tumors.
Dosage and Administration:
- The recommended dosage of Afinitor (Everolimus) varies depending on the specific condition being treated, the patient’s medical history, and other factors.
- It is usually taken orally once daily, with or without food.
- The tablets should be swallowed whole with a glass of water, and they should not be crushed, chewed, or split.
Potential Side Effects:
- Common side effects of Afinitor (Everolimus) may include:
- Fatigue
- Mouth sores
- Nausea and vomiting
- Diarrhea
- Loss of appetite
- Rash
- Headache
- Serious side effects can occur, including:
- Infections
- Severe allergic reactions
- Lung or breathing problems
- Kidney problems
- Blood clotting disorders
Precautions:
- Afinitor should be used with caution in patients with certain medical conditions, such as impaired liver function, impaired kidney function, or a history of lung disease.
- Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking before starting treatment with Afinitor.
- Regular monitoring of blood counts, kidney function, and liver function may be necessary during treatment with Afinitor.
Note:
Afinitor (Everolimus) is an important medication in the treatment of various types of cancer and non-cancerous conditions. Its use should be under the supervision of a qualified healthcare professional, and patients are advised to follow their healthcare provider’s recommendations closely for optimal safety and efficacy.
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