Description
Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
Formula: C28H38N6O11S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
PENEGRA-100
Overview: PENEGRA-100 is a pharmaceutical product manufactured by ZEE Laboratories containing the active substance sildenafil citrate. Each package contains 4 pills, each with a strength of 100 mg. PENEGRA-100 is primarily used to treat erectile dysfunction (ED) in men, helping to achieve and maintain an erection sufficient for satisfactory sexual activity.
Active Substance:
- Sildenafil Citrate: Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor. It works by increasing blood flow to the penis during sexual stimulation, resulting in an erection.
Indications: PENEGRA-100 is indicated for:
- Erectile Dysfunction (ED): It is used to treat men with erectile dysfunction, also known as impotence, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.
Mechanism of Action: Sildenafil citrate works by inhibiting the enzyme PDE5, which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP). cGMP is a molecule that relaxes smooth muscle cells, allowing increased blood flow to the penis. By inhibiting PDE5, sildenafil citrate enhances the effects of nitric oxide (NO), a natural chemical the body produces in response to sexual stimulation. This leads to increased cGMP levels, smooth muscle relaxation, and improved blood flow to the penis, resulting in an erection.
Dosage and Administration:
- Dosage: The recommended dose of PENEGRA-100 is 50 mg to 100 mg taken as needed, approximately 1 hour before sexual activity. The maximum recommended dosing frequency is once per day.
- Administration: The tablet should be taken orally with water. It can be taken with or without food, but taking it with a high-fat meal may delay the onset of action.
Potential Side Effects: While PENEGRA-100 is effective for treating ED, it may cause some side effects, including:
- Headache
- Flushing
- Dyspepsia (indigestion)
- Nasal congestion
- Dizziness
- Visual disturbances (e.g., changes in color vision, blurred vision)
- Rare but serious side effects include priapism (prolonged and painful erection), sudden hearing loss, and myocardial infarction (heart attack).
Precautions:
- Medical Supervision: PENEGRA-100 should be used under the guidance of a healthcare provider. It is important to discuss any medical conditions and medications you are currently taking, as sildenafil can interact with certain drugs, particularly nitrates.
- Contraindications: It is contraindicated in patients taking nitrates or nitric oxide donors, as this combination can lead to a dangerous drop in blood pressure. It should also not be used by individuals with a known hypersensitivity to sildenafil or any of the tablet’s ingredients.
- Alcohol: Limiting alcohol consumption is advisable as it can impair the ability to get an erection and may increase the risk of side effects.
In conclusion, PENEGRA-100 by ZEE Laboratories offers a reliable solution for men dealing with erectile dysfunction. With the active substance sildenafil citrate, it effectively enhances blood flow to the penis, helping to achieve and maintain an erection. When used responsibly and under medical supervision, PENEGRA-100 can significantly improve sexual performance and quality of life.
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