The global monkeypox outbreak began in Britain, which has the highest number of confirmed cases of the disease. The Health and Safety Agency (UKHSA) published its first technical briefing on the OUTBREAK of monkeypox in the UK on 10 June local time. According to the report, 99 percent of monkeypox cases interviewed in the UK were among men in their 30s and 40s, with many already showing symptoms in April. Geographic, multi-channel sexual networks amplify the spread of monkeypox virus. Mutations that occur in the monkeypox virus genome may affect the function of the virus proteins, including possibly making the virus more resistant.