Description
Entresto is a prescription medication that contains two active ingredients, sacubitril and valsartan. It is used to treat heart failure with reduced ejection fraction (HFrEF). It is marketed under the brand name Entresto.
Uses:
Entresto is used to treat heart failure with reduced ejection fraction (HFrEF), which is a condition where the heart does not pump blood as effectively as it should. It can help improve symptoms such as shortness of breath, fatigue, and swelling. It can also reduce the risk of hospitalization and death due to heart failure.
Storage Conditions:
Entresto should be stored at room temperature between 68°F to 77°F (20°C to 25°C). It should be protected from light and moisture. The tablets should not be stored in the bathroom or near any sources of heat.
Mechanism of Action:
Sacubitril and valsartan in Entresto work together to lower blood pressure and decrease the workload on the heart. Sacubitril blocks an enzyme that breaks down a protein called natriuretic peptides, which play a vital role in regulating blood pressure, salt, and fluid balance. Valsartan is an angiotensin receptor blocker that blocks the effects of a hormone called angiotensin II, which can cause the blood vessels to constrict, and the heart to work harder.
HOW TO USE:
The patient should follow the instructions of the healthcare provider when using Entresto. It can be taken with or without food. The tablet should be swallowed whole and should not be broken, crushed, or chewed. The dosage is based on the patient’s medical condition and response to treatment.
Precautions:
• Patients should inform their healthcare provider if they have any allergies, kidney or liver disease, diabetes, gout, or a history of angioedema.
• Entresto should not be used during pregnancy or breastfeeding.
• Patients should avoid drinking alcohol while taking Entresto.
Drug Interactions:
• Entresto may interact with other medications, such as diuretics, anti-hypertensives, or NSAIDs, which can increase the risk of side effects and decrease the effectiveness of the drug.
• Entresto should not be used with other ARBs or ACE inhibitors.
• Taking Entresto with potassium supplements or potassium-sparing diuretics can increase the risk of hyperkalemia.
Contraindications:
• Entresto should not be used in patients who have had a history of angioedema with previous ARBs or ACE inhibitors.
• It should not be used during pregnancy or breastfeeding.
• Entresto should not be used in patients with severe liver or kidney disease.
Overdose:
An overdose of Entresto can cause symptoms such as dizziness, rapid heartbeat, fainting, and low blood pressure. If an overdose is suspected, patients should seek emergency medical attention.
Adverse Reactions:
The most common side effects of Entresto include dizziness, low blood pressure, an increased risk of angioedema, and an increased risk of hyperkalemia. Other potential side effects include kidney problems, coughing, headache, and nausea. Patients should contact their healthcare provider if they experience any unusual symptoms while taking Entresto.
In conclusion, Entresto is a prescription medication used for treating heart failure with reduced ejection fraction. It is a combination of sacubitril and valsartan, which work together to improve symptoms and reduce the risk of hospitalization and death due to heart failure. It is important to follow the instructions of the healthcare provider, monitor for side effects, and avoid certain medications and activities while taking Entresto.
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