Description
Zokinvy (lonafarnib) is an oral medication used for the treatment of progeria, a rare genetic disorder that causes premature aging in children. It belongs to a class of drugs called farnesyltransferase inhibitors, which block the activity of an enzyme that is involved in the premature aging process.
Uses:
Zokinvy is used to treat progeria, a rare genetic disorder characterized by accelerated aging and associated health problems. It does not cure progeria but can slow down the disease progression and reduce associated complications such as heart disease and stroke.
Storage Conditions:
Zokinvy should be stored at room temperature, between 68°F and 77°F (20°C and 25°C), in its original container and away from moisture, heat, and light. It should be kept out of the reach of children and pets.
Mechanism of Action:
Zokinvy is a farnesyltransferase inhibitor that works by blocking an enzyme called farnesyltransferase, which is involved in a particular step in the process of cellular aging. This inhibition slows down the process of aging and can reduce premature aging symptoms in children with progeria.
HOW TO USE:
Zokinvy comes in tablet form and should be taken orally with or without food. The dosage is based on the patient’s weight and should be determined by the healthcare provider. Patients should take the medication as prescribed and should not stop taking it without consulting their healthcare provider.
Precautions:
• Patients should be monitored for signs of liver and kidney problems while taking Zokinvy.
• The medication may cause a decrease in red and white blood cell counts, which can increase the risk of infections and bleeding.
• Patients should be monitored for signs of infection, such as fever, sore throat, and flu-like symptoms.
• Zokinvy can cause birth defects and should not be used during pregnancy or breastfeeding.
Drug Interactions:
• The medication may interact with drugs that are metabolized by the liver, such as statins, leading to increased levels of these drugs in the body.
• Patients taking blood thinners should be monitored closely while taking Zokinvy, as it can increase the risk of bleeding.
Contraindications:
• Zokinvy is contraindicated in patients with a history of severe allergic reactions to the medication or any of its ingredients.
Overdose:
In case of overdose, patients should seek immediate medical attention.
Adverse Reactions:
The most common adverse reactions to Zokinvy include diarrhea, vomiting, nausea, abdominal pain, headache, and fatigue. Patients should notify their healthcare provider if they experience any unusual symptoms while taking Zokinvy.
In conclusion, Zokinvy (lonafarnib) is an oral medication used to treat the rare genetic disorder progeria that causes premature aging in children. It is a farnesyltransferase inhibitor that works to slow down the process of aging. It is taken orally and is contraindicated in patients with a history of severe allergic reactions to the medication or its components. Zokinvy can cause adverse reactions like diarrhea, fatigue, headache, and abdominal pain. Patients should be monitored for liver and kidney problems, as well as a decrease in red and white blood cell counts, while taking the medication. It may interact with drugs metabolized by the liver and blood-thinning medications. Patients should not use Zokinvy while pregnant or breastfeeding.
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