Description
Orilissa (elagolix) is a prescription medication used to treat endometriosis-related pain in women. It is available in tablet form and is taken orally.
Uses:
Orilissa is used to reduce menstrual pain and non-menstrual pelvic pain associated with endometriosis. It works by suppressing the production of estrogen, which is a hormone that contributes to the growth and development of endometrial tissue. By reducing estrogen levels, Orilissa can help alleviate endometriosis-related symptoms.
Storage Conditions:
Orilissa should be stored at room temperature between 20°C and 25°C, away from heat and moisture. It should be kept in its original container and out of the reach of children.
Mechanism of Action:
Orilissa works by blocking the binding of gonadotropin-releasing hormone (GnRH) to its receptor in the pituitary gland. This prevents the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are hormones responsible for the production of estrogen. By reducing estrogen levels, Orilissa can help alleviate endometriosis-related symptoms.
HOW TO USE:
Orilissa is taken orally, with or without food. The tablet should be swallowed whole and not crushed, chewed, or broken. The medication should be taken at the same time each day and for the duration prescribed by the healthcare provider.
Precautions:
• Orilissa can cause a decrease in bone density, so patients with a history of osteoporosis or bone fractures should inform their healthcare provider before starting treatment.
• Orilissa may increase the risk of suicidal ideation or behavior. Patients who experience any changes in mood or have a history of depression should inform their healthcare provider.
• Orilissa is not recommended for use during pregnancy or while breastfeeding.
Drug Interactions:
• Orilissa may interact with certain medications, such as rifampin or antiepileptic drugs. Patients should inform their healthcare provider of all medications they are taking before starting treatment with Orilissa.
Contraindications:
• Orilissa is contraindicated in patients with severe liver impairment or a history of liver disease.
• Orilissa should not be used in combination with certain medications, such as strong CYP3A inhibitors.
Overdose:
In case of an overdose of Orilissa, patients should seek immediate medical attention. Symptoms of an overdose may include nausea, vomiting, or changes in mental status.
Adverse Reactions:
The most common adverse reactions associated with Orilissa include hot flashes, night sweats, nausea, and headache. Other adverse reactions may include bone loss, elevated liver enzymes, or mood changes. Patients should inform their healthcare provider of any unusual or unexpected reactions while taking Orilissa.
In conclusion, Orilissa (elagolix) is a prescription medication used to treat endometriosis-related pain in women. It works by suppressing the production of estrogen, reducing the growth and development of endometrial tissue. Orilissa is taken orally and should be stored at room temperature, away from heat and moisture. Patients should inform their healthcare provider of any history of osteoporosis or bone fractures or changes in mood while taking Orilissa. Orilissa may interact with certain medications, and it should not be used during pregnancy or while breastfeeding. Adverse reactions may include hot flashes, night sweats, nausea, and headache. An overdose of Orilissa requires immediate medical attention.
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