Description
Ondexxya (andexanet alfa) is a medication used as an antidote to reverse the effects of specific blood thinners known as Factor Xa inhibitors. These medications are commonly used to prevent and treat blood clots. Ondexxya works by binding to and neutralizing the blood thinners, allowing the blood to clot normally.
Uses:
Ondexxya is used as an antidote for patients taking rivaroxaban, apixaban, edoxaban, or enoxaparin, who experience uncontrolled bleeding or require emergency surgery or interventions.
Storage Conditions:
Ondexxya should be stored in a refrigerator at 2°C to 8°C. The medication should be protected from light and not be frozen.
Mechanism of Action:
Ondexxya is a recombinant protein that acts as a decoy molecule to bind to and neutralize the effects of Factor Xa inhibitors, such as rivaroxaban, apixaban, edoxaban, and enoxaparin. By binding to these anticoagulants, Ondexxya allows the blood to clot and reduces the risk of bleeding.
HOW TO USE:
Ondexxya is administered by intravenous injection over 15 to 30 minutes. The dosage of Ondexxya is based on the specific Factor Xa inhibitor that the patient has been receiving and the time elapsed since the last dose. The healthcare provider may perform laboratory testing to assess the level of anticoagulation and adjust the dose accordingly.
Precautions:
• Ondexxya should not be used in patients with known hypersensitivity to the medication.
• Patients should be monitored for signs of thromboembolism, as Ondexxya may increase the risk of blood clots.
• The use of Ondexxya in pregnant women is not recommended.
Drug Interactions:
Ondexxya may interact with other medications that affect blood clotting, such as antiplatelet agents and other anticoagulants. Patients should inform their healthcare provider of all medications, supplements, or herbal products they are taking before receiving treatment with Ondexxya.
Contraindications:
• Ondexxya should not be used in patients with known hypersensitivity to the medication or to any of its components.
• The medication is contraindicated in patients with a history of arterial or venous thromboembolism.
Overdose:
There is no known risk of an overdose of Ondexxya. Patients should seek medical attention if any unusual symptoms develop after receiving the medication.
Adverse Reactions:
The most common adverse reactions associated with the use of Ondexxya are urinary tract infections, pneumonia, and infusion-related reactions such as headache, flushing, and decreased blood pressure. Patients should contact their healthcare provider if they experience any unusual reactions while using Ondexxya.
In conclusion, Ondexxya (andexanet alfa) is a medication used to reverse the effects of Factor Xa inhibitors commonly used to prevent and treat blood clots. Ondexxya is stored in a refrigerator, administered intravenously, and its dosage is based on the specific Factor Xa inhibitor and the time elapsed since the last dose. Patients should inform their healthcare provider of any medications they are taking before receiving Ondexxya. The medication has several contraindications, drug interactions, and precautions to be considered before consumption. Common adverse reactions are urinary tract infections, pneumonia, and infusion-related reactions.
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