Description
Bylvay (odevixibat) is a medication used to treat pruritus (itching) associated with progressive familial intrahepatic cholestasis (PFIC) in children aged 6 months and above and adult patients. PFIC is a rare genetic disorder that affects the liver’s ability to secrete bile acids, which leads to the accumulation of bile acids in the liver and other organs, resulting in severe itching.
Uses:
Bylvay is used to treat pruritus associated with progressive familial intrahepatic cholestasis (PFIC) in children aged 6 months and above and adult patients.
Storage Conditions:
Bylvay should be stored at room temperature between 20°C to 25°C (68°F to 77°F) in its original packaging. Do not expose the medication to excessive heat, moisture, or light.
Mechanism of Action:
Bylvay works by inhibiting the ileal bile acid transporter (IBAT), which reduces the absorption of bile acids in the intestines and lowers the level of bile acids in the liver and other organs. This mechanism prevents the accumulation of bile acids in the liver and other organs, which leads to a reduction in pruritus (itching) associated with PFIC.
HOW TO USE:
Bylvay is taken orally twice daily, with or without food, and the dosage is based on the patient’s age, weight, and other factors. The medication should be taken at the same time every day to achieve the best results. Bylvay should always be taken under the supervision of a healthcare professional.
Precautions:
• Bylvay should not be used in patients with known hypersensitivity to odevixibat or any of its components.
• Bylvay may cause liver function abnormalities. Patients should undergo liver function tests before starting treatment with Bylvay and regularly during treatment.
• Bylvay may interact with other medications, such as bile acid sequestrants or oral contraceptives. Patients should inform their healthcare provider about all medications, supplements, or herbal products they are taking before receiving treatment with Bylvay.
Drug Interactions:
Bylvay may interact with other medications that affect bile acid metabolism, such as bile acid sequestrants or oral contraceptives. Patients should inform their healthcare provider about all medications, supplements, or herbal products they are taking before receiving treatment with Bylvay.
Contraindications:
Bylvay should not be used in patients with known hypersensitivity to odevixibat or any of its components.
Overdose:
There is no specific information about the risk of an overdose with Bylvay. In case of an overdose, patients should seek medical attention immediately.
Adverse Reactions:
The most common adverse reactions associated with treatment with Bylvay include diarrhea, abdominal pain, and vomiting. Patients should contact their healthcare provider if they experience any unusual reactions while using Bylvay.
In conclusion, Bylvay is a medication used to treat pruritus (itching) associated with progressive familial intrahepatic cholestasis (PFIC) in children aged 6 months and above and adult patients. The medication works by inhibiting the ileal bile acid transporter (IBAT) and reducing the absorption of bile acids in the intestines. Bylvay is taken orally twice daily, with or without food, and should be stored at room temperature. Patients should take precautions, such as undergoing liver function tests and informing their healthcare providers of all medications they are taking. Bylvay may interact with other medications, and patients with hypersensitivity to odevixibat or any of its components should not use the medication. The medication has several adverse reactions, such as diarrhea and vomiting, and patients should contact their healthcare provider if they experience any unusual reactions.
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