Description
Pifeltro (doravirine) is a medication used to treat human immunodeficiency virus type 1 (HIV-1) infection in adult patients. It is an antiretroviral medication that belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Uses:
Pifeltro is used in combination with other antiretroviral medications to treat HIV-1 infection in adult patients who have not previously received antiretroviral therapy or who have achieved viral suppression on their current regimen and require a change in treatment.
Storage Conditions:
Pifeltro should be stored at room temperature (up to 25°C/77°F) in its original container. It should be protected from excessive heat, light, and moisture and kept out of the reach of children.
Mechanism of Action:
Pifeltro works by inhibiting the activity of the reverse transcriptase enzyme, which is necessary for the replication of the HIV virus. By blocking the enzyme, Pifeltro prevents the virus from multiplying and spreading within the body.
HOW TO USE:
Pifeltro should be taken exactly as prescribed by a healthcare provider. It may be taken with or without food. The dosage may vary depending on the individual’s weight, age, and medical condition. Patients should not change their dosage or stop taking the medication without first consulting with a healthcare provider.
Precautions:
• Pifeltro may cause a decrease in liver function. Patients with pre-existing liver problems should be closely monitored while taking this medication.
• Patients with a history of hepatitis B virus (HBV) infection should be monitored for reactivation of the virus during treatment with Pifeltro.
• Pifeltro may interact with other medications that are metabolized by the liver. Patients should inform their healthcare provider of all medications that they are taking while using Pifeltro.
Drug Interactions:
Pifeltro may interact with other medications that are metabolized by the liver. Medications that are inhibitors or inducers of the liver enzyme CYP3A should be used with caution while taking Pifeltro. Patients should inform their healthcare provider of all medications that they are taking while using Pifeltro.
Contraindications:
Pifeltro is contraindicated in patients with a known hypersensitivity to the medication. It should also not be used in patients who are taking certain medications that are metabolized by the liver, such as strong CYP3A inducers.
Overdose:
In the event of an overdose, patients should seek immediate medical attention. Symptoms may include nausea, vomiting, dizziness, and fatigue.
Adverse Reactions:
Common adverse reactions associated with the use of Pifeltro include nausea, diarrhea, and headache. In some patients, the medication may cause a decrease in liver function or an increase in liver enzyme levels. Patients should contact their healthcare provider if they experience any unusual reactions while taking Pifeltro.
In conclusion, Pifeltro is a medication used to treat HIV-1 infection in adult patients in combination with other antiretroviral medications. It is an NNRTI that works by inhibiting the activity of the reverse transcriptase enzyme and preventing the replication of the HIV virus. Patients should take the medication exactly as prescribed by a healthcare provider and should be monitored for possible liver problems. Patients should also inform their healthcare provider of all medications they are taking while using Pifeltro. While adverse reactions such as nausea, diarrhea, and headache can occur, patients should contact their healthcare provider if any unusual reactions occur.
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