As the saying goes: “an apple a day keeps the doctor away from me.” Eating apples often has many health benefits《 Exceed the standard or obesity incidence rate of people who eat apples every day can help reduce inflammation in the body and reduce the incidence of diseases such as cardiovascular diseases, which are closely related to inflammation, a new Canadian study published in the American Journal of clinical nutrition.
Dr. Lindsay Robinson, a researcher in the Department of human health and Nutrition Sciences at the University of Guelph in Canada, and his team of participants conducted a six week comparative study. The average age of participants was 45.4 years, and the average body mass index (BMI) was 33.4. The researchers randomly divided the participants into two groups. For the first two weeks, all participants avoided foods and beverages rich in polyphenols and dietary fiber. After that, in addition to the normal diet, the participants in group a ate three Gala apples a day (the edible part was about 200 grams), while the participants in group B did not eat apples. The intake of polyphenols and dietary fiber was limited for 6 weeks. Fasting blood samples were collected before and after 6 weeks to analyze the plasma biomarkers. The results showed that the levels of inflammatory markers such as fasting C-reactive protein, interleukin-6 (IL-6) and lipopolysaccharide binding protein in group A were 17%, 12.4% and 20.7% lower than those in group B, respectively. In addition, the levels of IL-6 and IL-17 secreted by PBMC decreased by 28.3% and 11%, respectively, and the plasma total antioxidant capacity increased by 9.6%. However, the new results also show that eating apples has no effect on weight loss, and has no effect on cardiovascular risk indicators such as blood glucose, insulin, blood pressure and blood lipids.
Dr. Robinson said the new findings suggest that eating apples every day is an effective way to reduce the chronic inflammation associated with obesity

With accelerated development in the field of early screening, the companies products, industry development, in the direction of the mature specification in education at the same time, focus on clinical research and market in the future how to solve the problem of multi-channel, pay problem, make cancer early screening, really meet the needs of clinical pain points and patients become cancer early sieve enterprise need to think about and layout problem.

“Partnering can bring 1+1.
All parties can make full use of their strengths to provide comprehensive services of ‘platform, technology, medical care and security’ for patients and their families, “Zhou Jun, CEO of Herui Genomics, told Caijing.
In the past year, Herui Genomics has been exploring cooperation with insurance, Internet companies, tumor imaging companies and many other role enterprises.
“This collaboration and ali health, is based on our people to disease classification and positioning for early screening target population, first of all on liver cancer early screening products out of the first step, but will also continue to cooperation, will explore more likely, from medicines to insurance, even based on ali health data for clinical exploration and development technology, and more cooperation in the future.”

“Only by forming a closed loop can we call it a complete early screening program.”

Announced a few days ago, ali health officially launched “slow disease protection scheme”, introduced millions of health care service “hepatitis b protect”, according to ali’s health, according to demand of hepatitis b patients with buy medicine and protection, can choose many hepatitis b daily medicine, if the insured person to cirrhosis of the liver, unfortunately by the applicant for liver cancer early screening, even after the diagnosis of liver cancer,
The insured will also receive expert consultation services provided by Ali Health and reimbursement of medical expenses for liver cancer provided by Zhongan Insurance.

The whole project in the middle of the ring is in a high-risk population screening for link, this part of the crowd in turn cancer risk compared with the general significantly increased in patients with liver disease, “this and our people to disease classification and early screening the positioning of the target population is the same, we need to identify high-risk in slow disease, extremely high risk people”,
In this project, by providing the early screening product of liver cancer, Lathning, HerueGenomics set up an online and offline integrated health service mode, providing solutions including prevention, screening, treatment and rehabilitation for people at high risk of liver cancer. Together, HerueGenomics has opened a closed loop of “medical treatment + medicine + testing + insurance”.

“This collaboration is the first step based on HCC early screening products, but the collaboration will continue, and more possibilities will be explored, ranging from drugs to insurance, and even clinical exploration and development based on Ali Health data technology, as well as cooperation on more products in the future,” Zhou told Caijing.

In the field of early screening and diagnosis of tumors, Herugenomics has launched a series of clinical research projects on early screening and early diagnosis of tumors, including liver cancer, lung cancer and other high-risk tumors in China. The clinical grade liver cancer early screening product Lesning has been launched in August 2020.
With the launch of products and the rapid development of the industry, while focusing on clinical research and market education, cancer early screening companies need to think and layout about how to solve the problem of multi-channel and multi-payment in the future, so that cancer early screening enterprises can truly realize the implementation of clinical pain points and patients’ needs.

In this project, the two sides will provide users with multi-level health security system and compensation system, “lai si ning” as part of an insurance premium services, and in the past few months, and gene is active cooperation and more insurance companies to explore, in March 2021, and genes and taikang online, anhua agricultural insurance also reached a cooperation, respectively.

“Medical insurance is the ideal, while commercial insurance is the reality,” said Zhou Jun frankly. Public hospitals in China are the dominant ones, and patients in hospitals are one of the main business models for early screening products. Cancer early screening still needs to be paid by oneself.
The second is to adapt to the clinical environment in China. What are the needs of the patients? The examination alone cannot solve the problem of payment or diagnosis and treatment, so it cannot be called a complete early screening program.”

In his view, building a Chinese program for early cancer screening and prevention requires the integration of all aspects, from commercial to clinical, from technology to industry.
“In the future, the company will continue to deepen the depth and breadth of cooperation with partners, expand the layout of cancer early screening product line, inject new momentum into the research and development of high incidence and high-risk cancer early screening in China, and work with ecological partners to realize the mission of ‘early diagnosis and early treatment for all tumors’.”

“Clinical grade early screening products depend on the data”

According to ali, health, vice President, noting, “based on the health of the whole scene ali medical service capacity, and high specificity of genome and gene detection technology and large sample clinical research, the further cooperation is the comprehensive exploration on the disease care, and will use science and technology innovation, around more diseases to design a new model of health management.”
Zhou Jun also revealed that Ali Health had done a lot of “back research” before choosing Hexigen, and had made an understanding of the technical path and clinical data of the product.

A clinical-grade early screening product still depends on the data.
In 2020, Hereogen announced the roadmap for early screening and early diagnosis of multiple tumor species:
Within three to five years, Herui Genomics will deliver research results on early screening and early diagnosis of 5 to 8 types of high-risk and high-incidence tumors in China, and carry out industrial implementation. Lesning will be launched in August 2020 for the screening of liver cancer in high-risk groups, which is 6-12 months earlier than the traditional method for the early warning of liver cancer.
The related achievements of HIFI technology have also been published in the international authoritative journal Cell Research (IF=20.5), which has been recognized by international authorities.

On June 22, the Chinese Journal of Liver Diseases officially published the first expert consensus on early screening strategies for liver cancer in China, which was led by the national multi-center prospective screening program for extremely early warning of liver cancer (PRECAR).
Herui gene cfDNA whole genome sequencing technology for early screening of liver cancer is incorporated into the “pyramid” model for early screening of liver cancer. Through the model of preliminary screening, fine screening and early diagnosis, the risk groups are enriched and concentrated layer by layer, and the detection efficiency of early liver cancer is finally improved.
The Consensus showed that the HIFI scoring model based on cfDNA whole genome sequencing had a stable performance, with a sensitivity of 95.42% and specificity of 97.91% to distinguish between HCC and non-HCC.

“A product can’t solve a clinical problem and will eventually degenerate into a consumer product,” Zhou Jun told Caijing.com. “China’s clinical environment is centered on clinicians, and doctors’ opinions and opinions are very important to the implementation of early screening products in the whole society.
At the same time, the approval of clinicians is not only an endorsement, we want to provide early screening program, the other end of the cancer diagnosis and treatment loop occurs in the clinic, the screening results must be accepted by the clinic, the clinical program can be adjusted accordingly, if the clinic is not recognized, this value will be greatly reduced.
Based on these two factors, we think it’s time to put resources into the clinic.”

In April of this year, the Precar program announced new progress and will launch the Ⅱ phase III clinical application extensibility study, which extends from early screening to the management of the entire course of HCC.

Why the Ⅱ phase III trial?
“One is to give people a better understanding of the performance and clinical use of our products, and the other is to help doctors deepen their understanding of clinical testing,” said Zhou Jun.

About how to understand to the whole course of the management of liver cancer, he explains the financial network, “the first is about some malignant nodules, because now we say that the liver is above there are a lot of nodules, cirrhosis of the liver itself has nodules, how to determine the clinical doctors are interested in, which is originated in the us with clinical doctors to do some tests, and see if I can do the judgement of nodules.
The clinician also mentioned that since early screening can be done to detect recurrence, “the underlying technology is similar, we will make some adjustments, and we will judge whether it can adapt to the actual clinical results, and finally illustrate with data.”

As the saying goes, “one fat destroys all”, with the development of society, obesity and related metabolic diseases incidence rate continues to rise. Obesity has brought great influence on people’s health and even life. As a leader in the field of weight loss and metabolism, Youdao doctor group has completed more than 2000 cases of weight loss surgery so far, bringing new hope to fat friends.
In fact, weight reduction surgery is to reduce the digestive tract absorption and digestive area through surgical means, so as to achieve the purpose of reducing the weight of patients. Weight loss surgery can not only reduce the weight of patients, but also improve or even cure the metabolic complications caused by weight gain and obesity, such as hypertension, diabetes, hyperlipidemia, hyperuricemia, polycystic ovary syndrome, sleep apnea syndrome, and so on. All these are all necessary for weight loss surgery to assist in controlling diet to lose weight.
At present, weight loss surgery as a long-term effective method to lose weight, not every fat person is suitable for weight loss surgery. Body mass index (BMI) is an important standard to judge a person’s degree of obesity. It is calculated by dividing the kilogram value of weight by the square of the height value (CM).
Dr. Yu said that according to the guidelines for surgical treatment of obesity and diabetes in China, there is definite indication for weight loss surgery: BMI 32 or more recommended for weight loss surgery. If 27.5 ≤ BMI < 32.5, and there are two metabolic diseases, such as hypertension, hyperglycemia, hyperuricemia, hyperlipidemia, polycystic ovary and other diseases, weight loss surgery can also be considered.
Now the most commonly used weight-loss surgery is gastric bypass surgery and sleeve gastrectomy. Which is better? How should patients choose? In fact, it depends on the patient’s physical conditions and their own situation.
If the degree of obesity of patients is relatively high, and BMI is more than 40, then gastric bypass surgery, weight loss effect will be more ideal, can achieve the best effect of long-term weight loss. If the BMI of the patients is less than 40, the weight loss effect of sleeve gastrectomy can make the patients get good weight loss effect, because it does not need to lose more weight and fat.
In general, with the progress of medical technology, weight loss surgery has become a routine and safe treatment for obesity, which is a good choice for weight loss. However, fat friends need to choose the right way to lose weight according to their own physical conditions.

As the “important component” of supporting human upright walking, knee joint maintenance is very important. Once it is damaged, it will affect the movement and the quality of life. The causes of knee pain are complex and diverse, which are very common in young people to middle-aged and elderly people of all ages. How to make good use of the knee, maintain the knee joint and prolong the “service life” as far as possible? Zhao Chang, deputy chief physician of the Department of joint surgery and sports medicine of the Third Hospital of Southern medicine, came to help.
There are many reasons for knee pain
Early maintenance
Zhao Chang said that one third of the patients who seek medical treatment due to bone and muscle problems are related to the knee joint, and about 25% of the adults have suffered from knee joint pain. If they are professional athletes, the proportion can be more than half.
The causes of knee related acute pain include fracture, meniscus injury, ligament injury, tendinitis, bursitis, gouty arthritis, infectious arthritis, etc; Chronic pain may be caused by osteoarthritis, rheumatoid arthritis, synovitis, popliteal cyst, patellofemoral joint disease, etc.
The early diagnosis and treatment of knee joint disease is very important. If there are severe pain, obvious swelling, inability to stretch and bend, weight bearing, difficulty in standing and walking, joint pain and ringing and other symptoms, which are not improved for several weeks, it is recommended to seek medical consultation immediately.
Running doesn’t necessarily hurt the knee
Running knee
Whether it is easy to hurt the knee when running frequently has always been controversial. Is it true that running hurts the knee?
Zhao Chang said that the data showed that the incidence of arthritis in runners was 13.3%, that in sedentary people was 10.2%, and that in amateur runners was only 3.5%. For ordinary fitness runners, running is conducive to joint health, reasonable, moderate, moderate running will not hurt the knee. But excessive and intense running can cause joint problems. Patellofemoral joint disease is the most common cause of knee joint pain in young people. It is common in young people who love running, especially in long-distance running. This is the legendary “running knee”. Its incidence is about 20%, accounting for half of the clinical knee pain.
In addition to pain and swelling, the common symptoms of the running knee include strong pain in the front of the knee when going up and down stairs or squatting, and “click” or “rustle” when stretching and flexing. In addition, still walking or standing when “soft legs.”.
The treatment of “running knee” is mainly non-surgical treatment, including drug therapy, massage, physical therapy, muscle exercise and so on. When the symptoms appear, the knee joint should be limited to vigorous activity for 1-2 weeks to avoid further cartilage damage. When swelling, pain suddenly intensified, can first cold compress, reduce joint swelling, two days later hot compress. When the standard non-surgical treatment is ineffective or the symptoms gradually worsen, surgical treatment can be considered.
Why does knee osteoarthritis increase in young people?
Knee arthritis is another common cause of knee pain. Studies have shown that osteoarthritis is common in different parts of the elderly female population, and the incidence rate of knee joint is the highest. Is knee arthritis inevitable when people are old? Now more and more young people will be diagnosed with knee arthritis, and why?
Zhao Chang said that as a chronic systemic disease, osteoarthritis is also a degenerative change of articular cartilage, which is really closely related to age. However, the “age” of the knee joint is not necessarily proportional to the actual age of the person. It does not mean that people will definitely have knee arthritis when they are old, nor that young people will not get sick, especially young people who often take strenuous exercise or use incorrect exercise methods will have a higher risk of getting sick. In a word, the key is maintenance.
In the early stage of knee arthritis, there may be pain after going up and down stairs and exercise, and the rest will be improved. In the middle stage of development, it may show pain when moving joints or walking, and gradually develop to pain even when resting or at night, even deformity and limited activity, which affects life.
Routine maintenance of knee joint
Zhao Chang said that daily maintenance of the knee, first of all, to start from reducing weight, obese people, knee will consume more. For every kilogram of weight lost, the knee joint will be several times easier.
Secondly, long-term flexion and adduction walking can accelerate cartilage wear. For those with early symptoms, wearing the corresponding brace can alleviate the progress of osteoarthritis.
Thirdly, avoid sports injury. Warm up before exercise, pay attention to the standard movement, choose the appropriate venues and sports equipment, pay attention to physical fitness, muscle strength, flexibility, coordination training, avoid excessive fatigue and forced exercise. We should choose the type and intensity of exercise according to individual physical fitness and physique. Ordinary people suggest that the increase of exercise time and intensity per week should not exceed 10% of the previous week; If there is obvious discomfort on the next day after exercise, we should take a proper rest.
Diet, should pay attention to eat fresh fruits and vegetables, supplement vitamin C, D, middle-aged women appropriate supplement folic acid, are very beneficial to knee health.
It is also an important intervention measure to prevent knee joint disease to improve the poor alignment of lower limbs. Knee varus and valgus are common in daily life, that is, O-shaped legs and X-shaped legs. The knee joints of this kind of people are easier to relax and accelerate wear, and the risk of knee osteoarthritis is several times higher than that of normal people. Therefore, if it is serious, we should consult the doctor as soon as possible.
If the knee joint has been worn and degenerated to a certain extent, attention should be paid to:
Don’t exercise for too long. When the knee feels uncomfortable, take a rest immediately.
Do not do large amount of exercise, such as fast running, high jump, long jump.
Do not do the knee half flexion rotation to prevent meniscus injury.
Keep your ideal weight to reduce the load on your knees.
Pay attention to keep your knees warm. You can wear trousers and kneepads to protect your knees.