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Early CAR T Therapy Enhances Outcomes for High-Risk Tumors

Early introduction of a treatment called AXI-CEL could improve the performance of high-risk tumors, according to a phase ii trial conducted by U.S. scientists and published in The Journal Nature Medicine. It activated a complete response in 78% of 37 high-risk large B-cell lymphoma (LBCL) patients. Axi-cel is a CAR-T immunotherapy that specifically targets the surface protein CD19 of cancerous B cells. The results suggest that this type of CAR T cell therapy is safe, early or more clinically beneficial than usual.

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UN Secretary-General: 11 Billion COVID-19 Vaccine Doses Needed for Global Herd Immunity

United Nations Secretary-General Guterres stated on the 13th that to achieve global herd immunity and end the new crown epidemic, 11 billion doses of vaccine are needed for vaccinations in 70% of the world.

Guterres said at the opening ceremony of the ministerial meeting of the United Nations Economic and Social Council’s High-level Political Forum on Sustainable Development that he welcomed the international community’s commitment to provide vaccines and funds, but that was not enough. He emphasized: “Everyone must be able to get the new crown vaccine, virus testing, treatment and various other supports.”

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Androgen Levels Remain High in Men Over 55

Androgen is very important for maintaining male characteristics and physical health. It is precisely because of it that men have masculinity and healthy body.

In general, male hormone levels gradually decline with age. However, many men still have high levels of male hormones after they reach the age of 55. Is this normal?

Before answering this question, let’s take a look at the performance of men with high male hormones. Under normal circumstances, if the following characteristics are met, male hormones are relatively strong.

More muscles in the body

People with strong male hormones have more muscle content. Although most men are not muscular, they also have a lot of muscles. Such men generally do not lack male hormones. However, it is not necessarily for people with fat. Obese men generally do not secrete much male hormones.

The leg hair is still very strong

Many men have relatively strong leg hair. Some men feel that they are an eyesore, so they want to shave it off. In fact, strong leg hair is a manifestation of more male male hormone secretion, and it is also a manifestation of good health. Under normal circumstances, men with more hairy legs have very good physical fitness.

Warm hands and feet, better facial complexion

Androgens can promote the circulation of qi and blood in the body, so that all tissues and organs of the body can be adequately nourished, so the limbs are warm. At the same time, because the body has enough blood, the facial complexion is naturally very good, the whole person looks very energetic, and it is not easy to get tired when doing things.

Sleep quality is generally better

Sleep is very important to the human body. Under normal circumstances, the time spent on sleep every day accounts for about 8 hours, which accounts for almost one-third of the day. Therefore, the quality of sleep has a great impact on health. What many people don’t know is that the quality of sleep has a lot to do with hormone levels in the body. Males with strong male hormones generally have relatively stable endocrine, high sleep quality, and rarely wake up at night.

After 55 years of age, men also have the above several characteristics, which indicate that the male hormones in the body are relatively strong and the body is in a relatively healthy state.

So, is male hormone prosperous after 55 years of age good or bad? In fact, more is not the better.

If there is too much androgen, it will increase the risk of men suffering from prostate disease. If there is inflammation, too high androgen is like adding fuel to the fire and will aggravate the condition.

In other words, too high or too low male hormones are not good for the body, and it is best to keep them within the normal range. In real life, low male hormones are more common. Therefore, more attention should be paid to the impact of male hormone deficiency.

So, in life, how do we supplement male hormones?

Eat healthy and nutritious

To maintain sufficient male hormones, one should first start with diet. Eat as little junk food as possible, especially high-fat, high-calorie, and high-sugar foods. These foods not only increase the risk of obesity, but also affect the secretion of male hormones. Eat more healthy and nutritious foods, especially foods rich in zinc. Zinc-containing foods can promote the secretion of male hormones in the human body and help maintain adequate levels of male hormones.

Drink more water

Water is a very important component of the human body. Only by maintaining enough water can the body’s metabolism become better, and the toxins and garbage in the body can be discharged in time, which is very conducive to the secretion of male hormones. When drinking water, try to drink warm water or pure water, and it is best not to drink all kinds of unhealthy beverages.

Insist on exercising moderately

Exercise can improve physical fitness and transform the aroma of androgens in the brain to produce male hormones. At the same time, exercise can enhance cell activity, and is also conducive to the secretion of male hormones, allowing the body to maintain normal androgen secretion.

Do more aerobic exercises, such as jogging, squatting, and swimming.

In addition, exercise should be moderate, about 3 times a week, about 30 minutes each time, do not exercise too much. Excessive exercise is easy to damage the muscles, but it causes the speed of cell synthesis to slow down.

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Liver Cirrhosis Is Linked to Lifestyle Choices

Introduction: Nowadays, people don’t care much about their eating habits. They always do what they want to do. However, their own Gehong’s disease surrounds them. What causes liver cirrhosis? When people understand cirrhosis, can cirrhosis be prevented?
01
What is cirrhosis
Cirrhosis is the change of liver sclerosis, most of which are caused by some viruses, drugs or alcohol, or previous diseases such as blood sucking worms. The liver tissue gradually hardens, and the blood in the gastrointestinal tract cannot flow back to the liver smoothly, resulting in abnormal liver function. Ascites, esophageal varices, hypersplenism and other diseases may also occur.
Because the early symptoms of liver cirrhosis is not obvious, so many people do not take it seriously, leading to deterioration of the disease, serious cases will appear hematemesis, a large number of ascites can not be relieved, and finally the disease developed to cancer. Therefore, cirrhosis should be found, examined and treated as soon as possible. Therefore, early treatment of liver cirrhosis will be more time-saving, labor-saving, money saving, and achieve better results.
Decompensated cirrhosis is one of the complications in the development of cirrhosis, such as ascites, hypersplenism, gastroesophageal varices and so on. Patients are very dangerous when they enter the decompensated period, and these complications are easy to lead to the final death.
02
Causes of liver cirrhosis
Hepatitis B, C and D viruses are responsible for 40% ~ 65% of viral hepatitis in cirrhosis in China. The main pathogenesis is chronic hepatitis, especially chronic active hepatitis, and gradually develops into cirrhosis. Therefore, once again, we must not delay getting hepatitis.
Infection with Schistosoma or Clonorchis sinensis can lead to parasitic cirrhosis. Many rural areas have this situation, water with schistosomiasis must not go to alcoholic liver cirrhosis, accounting for about 7% of the patients with liver cirrhosis in China, but in recent years, with the improvement of people’s material living standards, China’s consumption of alcohol increases year by year, the number of people with liver cirrhosis is also increasing step by step. Nonalcoholic steatohepatitis, commonly known as fatty liver, can be diagnosed as fatty liver if the intrahepatic fat content exceeds 5%, while about 20% of nonalcoholic steatohepatitis develops into cirrhosis. Pregnant women with syphilis through the placenta to the fetus and the possibility of syphilis. This shows how important pre pregnancy physical examination is. Liver function examination is of great significance for the diagnosis and treatment of liver cirrhosis. Once abnormalities are found, we must actively treat them, otherwise with the development of the disease, it will pose a great threat to the lives of patients with liver cirrhosis.
Liver stem cells produce diffuse proliferation of fibrous tissue on the basis of necrosis, which eventually leads to the damage of normal liver tissue function. Early liver without any symptoms, and even liver function has not changed significantly, but to do a good job in the daily work of liver protection. If there is transaminase rise, jaundice, must be abnormal liver function. At this time to timely medical treatment, to avoid liver dysfunction, cirrhosis and other situations.
03
People’s understanding of liver cirrhosis
In the past, once liver cirrhosis occurs, it is irreversible. However, with the continuous development of medicine, the situation of early cirrhosis can be reversed, and some special drugs can be used to reverse the substance of liver fibrosis.

  1. Symptoms of liver cirrhosis
    First of all, early cirrhosis, most of the time will not have any clinical symptoms, so early cirrhosis is difficult to use the external performance of the human body to judge. That is, at this time, cirrhosis is still in the compensatory period, but also to meet the normal physiological needs of the human body. In the middle stage of liver cirrhosis, there will be some abnormal indicators and jaundice symptoms. There may also be ascites, abdominal distension, lower limb edema and other symptoms. Transabdominal B-ultrasound can clearly find the patient’s ascites.
    It is the decompensated period of liver cirrhosis, which is usually the late stage of liver cirrhosis. At this time, it can not meet the needs of the human body. The symptoms of jaundice, ascites, loss of nutrients, hypoproteinemia, anemia and other symptoms will appear. Liver disease liver cirrhosis liver cancer is a typical liver disease in trilogy.
    According to statistics, 15% of liver diseases develop into cirrhosis every year in China, of which 70% is hepatitis cirrhosis, and liver cancer is mostly caused by hepatitis B cirrhosis. The incidence rate of liver cancer is about 55% in China. It has become a major killer of health and life of people. Liver disease is a kind of chronic progressive liver disease caused by many reasons. Viral hepatitis in China is mainly related to the long-term delay of hepatitis B, C and D.
    In recent years, with the improvement of people’s living standard, the diet structure and habits have undergone great changes, which has caused the incidence rate of alcoholic hepatitis and non-alcoholic steatohepatitis to rise obviously, which is an important reason for the formation of cirrhosis. In addition, cholestasis, schistosomiasis infection, chemical or drug factors, heredity, some metabolic diseases and so on are the causes of liver cirrhosis.
    Liver disease has the characteristics of occult onset and slow progress, so in the compensatory stage of liver cirrhosis, the symptoms are mild and atypical, mainly manifested as anorexia, fatigue, fatigue, abdominal distension, diarrhea and other symptoms. However, if the development of decompensation, the symptoms are more obvious and typical, such as emaciation and fatigue, liver disease, loss of appetite, anorexia, nausea and vomiting, diarrhea, due to severe damage to liver cells, liver function decline, the patient may appear bleeding tendency, and poor blood, such as gingival, nasal, gastrointestinal bleeding, skin purpura, etc. Because the liver’s inhibitory effect on estrogen is weakened, the patient will have typical liver palms (red spots appear on the thenar the size of the palm) and spider nevus (small arteries of the skin dilate like spiders). In addition, splenomegaly, ascites (the most prominent manifestation of liver cirrhosis) and other symptoms may appear in decompensated stage.
  2. Complications and prevention of liver cirrhosis
    Upper gastrointestinal bleeding: one of the most typical complications of decompensated cirrhosis, mainly acute hematemesis or melena. Hepatic encephalopathy: the most fatal complication in patients with advanced liver cirrhosis, is also a common cause of death. Infection: due to patients with low immune function, can cause a variety of bacterial infections, severe cases can occur septic shock. Complications include hepatorenal syndrome and hepatopulmonary syndrome.
    The safest and most effective measures to prevent hepatitis B are vaccination, such as paying attention to diet, drinking water sanitation, vaccination, etc. For all kinds of hepatitis patients, should be actively treated, regular physical examination, and actively review. To change bad living habits, we can start from daily life, such as stay away from drunkenness, three high diet, sedentary and overeating. In addition, we should do aerobic exercise 3-5 times a week to ensure a good mood and actively control weight.
    Conclusion: liver cirrhosis has always existed in people’s lives, but it is not so existential. People only realize that in the eyes of this disease when they feel uncomfortable, the prevention of liver cirrhosis is people’s greatest responsibility for themselves.
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