Friend of a lot of hepatitis, after appearing lack of power, appetite drops, disgusting wait for alimentary canal symptom, also can feel liver area ache sometimes, what reason is this?

Pain in the liver, it’s not pain in the liver, because there’s no pain nerve distribution in the liver, so a lot of people don’t feel pain when the liver tissue is damaged.
Then why can feel liver area again when a lot of hepatitis break out unwell, ache even?
The main reason is in the envelope of the liver.
The capsule of the liver has a very thin capsule, which contains rich distribution of painful nerve endings. As long as the capsule is stimulated, there will be a feeling of pain.

In clinical practice, when some patients need to do liver puncture examination, they need to use some anesthetic, just to anesthetize the capsule of the liver and reduce a lot of pain.
Additional, when hepatitis activity, no matter what cause of disease, want liver organization to be congestive because of inflammation, oedema only, can make liver volume increases, bring about liver envelope to stretch tight, appear tension rises, this can stimulate the pain nerve of liver envelope at this time, ache feeling was produced.
Similarly, if a doctor palpates an enlarged liver during a physical examination of a friend suffering from hepatitis, sometimes the patient will also feel pain, which is also a manifestation of irritation of the liver envelope.

So, appeared when hepatitis patient nauseous, vomiting, abdominal distension, appetite drops the symptom such as, when companion liver area aches at the same time, need affirming or exclude having hepatitis activity, so that discover in time exists liver injury, ability is treated actively, prevent the progress of liver disease.

A group of medical workers rushed into the emergency room pushing the ambulance. Outside the door, a woman who looked to be less than 50 years old sat on a stool and shed tears. After understanding the whole story, it was discovered that the woman crying outside the door was surnamed Wei.
When I went out this morning, someone called Ms. Wei to say that her daughter was riding an electric bike and another car crashed into her. Miss Zhao was in pain and was rushed to the hospital.

Such as emergency rescue after the doctor came out from the office, Ms. Wei rushed up and asked her daughter’s situation, the doctor explained that miss zhao although 25 years old this year, but his age as 50 – year – old man, this is caused by the brittle fracture of osteoporosis, but no injury and the hip joint, although it was in stable condition,
But need long-term lie in bed cultivation, and the method that does not have thorough and radical cure osteoporosis on medicine at present, want extra attention to raise bone in the life after so.

A woman in Shandong Province was admitted to hospital with bone fracture and found to have osteoporosis. Her family cried bitterly that she was still so young

After hearing this sentence, Ms. Wei felt the sky fall down and cried even louder. How could her daughter be so young and osteoporosis? The doctor explained:
Osteoporosis in addition to related to age, and also a lot of habits and diet has a lot to do in life, eating habits may accelerate their bone loss, regardless of age group has the risk of developing osteoporosis, young people often suffer from osteoporosis in recent years, after the doctor found after communication with miss zhao,
All this was due to some bad diet in her life.

Doctor prompt: young detection of osteoporosis, or with life in 3 kinds of diet

1, milk tea,

According to the doctor to know, miss zhao is a very like to drink tea with milk, especially often see the milk tea shop in the street, see after will be in to buy a cup, but this kind of milk tea contains a large number of saccharin, if drink too much, will affect their insulin secretion, thereby inhibiting the production of growth hormone, lead to loss of hormones involved in bone construction,
Causes oneself bone volume to produce to reduce, created the condition for the osteoporosis arrival.

2, tremella

Miss zhao is also a beauty of the person you like, at ordinary times is also listen to other people say tremella lotus nuts sweet soup helps beauty to raise colour, but tremella is a kind of phosphorus content of more food, eat much can lead to excessive phosphorus in bone, though it is also the important component of the bone, but that would inhibit bone for the absorption of calcium,
Phosphorus – only bones are unable to make new bone cells, reducing their bone mass.

3, kale

Miss zhao on a diet at ordinary times like to eat vegetable salad, which is essential to the cabbage, but it belongs to a kind of high oxalate vegetables, if not treated with hot water before eating, so these oxalic acid as the esophagus into the human body, lead to the occurrence of calcium oxalate, will not only impair kidney function, calcium will accelerate bone loss, bone injury.

Ms. Wei learned that her daughter suffered from osteoporosis is the real reason for regret, only hate themselves in the usual no good health supervision of her, the doctor explained that although there is no complete treatment of osteoporosis, but as long as in life to improve bad habits, more than 1 thing, is completely can control the disease.

If you want to stabilize the bone, reduce their own disease, supplement 1 is the key

1 substance — psoralein

Actually fill bone leaf glycosides is composed of a variety of Chinese herbal medicine components meals, this kind of material is contained in extract belongs to small molecules, can gently to promote bone absorption of some nutrients, and repair the bone leaves glycosides itself contains chondroitin sulfate this sugar glycosaminoglycans, can supplement necessary for bone minerals and vitamins, to promote the physiological activities of the bones.

Filling bone leaves glycosides is contained in eucommia ulmoides, malaytea scurfpea fruit, and epimedium in huangdi neijing have mentioned are filling bone substance, can adjust the speed of bone formation and bone loss in bone to ease their bone loss, increase their bone density, alleviate effect, and repair the bone leaves glycosides of epimedium can also maintain the endocrine,
It can effectively avoid bone loss caused by hormone problems, and has a certain preventive effect on osteoporosis. Therefore, it is suitable for people with bone loss to relieve and consolidate bone mass.

Pain perception is one of the basic senses of human beings and higher animals. Its function lies in making the organism benefit and avoid harm and keep away from risk.
But in many cases, chronic and long-term severe pain has not only lost the significance of warning of danger, but also will bring great physical trauma and psychological pressure to patients.

On March 10, researchers at the University of California, San Diego, published a paper on gene therapy for pain in the journal Science Translational Medicine.
The study found that modifying the pain gene in mice with gene therapy can reduce the pain perception in mice for a period of time, and does not permanently disable the pain sensing system.

The results in mice suggest that chronic pain, which affects quality of life in humans, could be overcome by cutting-edge gene therapy.

How do traditional painkillers work?

Each of us may experience severe chronic pain at some point in our lives. Pain not only causes pain to the patient, but also adversely affects the central nervous system, circulation, respiratory, endocrine, digestive and autonomic nervous systems.
According to a survey conducted in the United States in 2018, 20 percent of American adults experience chronic pain and 8 percent say it has seriously affected their normal life.

Physical pain usually refers to the discomfort caused by physical injury, illness or adverse external stimuli.
Pain is a common or major symptom of many diseases, such as headache caused by brain tumors, chest pain caused by coronary heart disease, biliary colic and abdominal pain caused by gallstones, and cancerous pain in patients with advanced tumors.
Some pain is a disease in itself, such as herpes zoster neuralgia and trigeminal neuralgia.

Like other sensory systems in the body, pain is generated by the coordination of pain receptors located throughout the body and the central nervous system, such as the brain.
For example, when we accidentally touch a hot stove, pain receptors located in the skin will send the external stimulus through the nervous system to the brain, where the pain center of the brain will form a “pain” sensation.

Pain receptors throughout the body work with the central nervous system, such as the brain, to create pain.
| comes from the network

Sometimes, even though pain receptors throughout the body don’t actually feel pain, there’s damage to the nervous system that’s responsible for transmitting pain signals, and pain can form in the brain. This is neuropathic pain.
In addition to the above two kinds of pain, there is a relatively rare pain called psychogenic pain.
This kind of pain is the central nervous system has the pathological change, causes the patient to appear the painful feeling without the pain stimulation circumstance.

At present, the human to pain is not completely countermeasure, all kinds of painkiller is undoubtedly one of the greatest inventions in human history.
But common home pain relievers only relieve mild pain and only last for a few hours.
The opioid painkillers, which are used to relieve severe pain in clinic, have serious side effects such as addiction.
Moreover, as the body becomes more and more adaptable to the drug, the effectiveness of the treatment will decrease significantly over a period of time.

The root cause is that many traditional painkillers act directly on the central nervous system of the human body. Therefore, while affecting the pain center, they will also interfere with the normal function of other centers, causing side effects such as vomiting, lethargy, constipation, dizziness and even cramps.
Addiction and tolerance are also related to their action on the central nervous system.

So, is there a way to avoid the impact on the central nervous system and make the pain disappear completely within a certain period of time without affecting other bodily functions?

Is Pain Controlled by Genes?

The team focused on a human gene called SCN9A.
The gene is highly active in nerve cells outside the brain and spinal cord, in the peripheral nervous system.
Once it is disabled, the ability to perceive pain is turned off.
And when this is overexpressed, people become unusually sensitive to pain.

Generally speaking, gene expression is the process by which genetic information (DNA or RNA fragments) expresses itself as external traits by guiding the synthesis of living macromolecules (proteins, etc.).
The genes that control hair color, for example, can make our hair look different by controlling the proportion of eumelanin and melanin in our hair.

SCN9A is a gene that controls human’s ability to feel pain, and its expression level and way will largely determine a person’s ability to feel and tolerate pain.

Specifically, the pain gene acts on a special sodium channel in nerve cells (Nav1.7), which plays a role in transmitting pain information from peripheral nerves to the brain.
In other words, the pain gene does not act on the central nervous system itself, but only on the process by which the peripheral nerves transmit information to the central nervous system.
If there were a way to safely weaken the signaling of sodium channels, chronic pain might no longer be a problem.

The human ability to feel pain is controlled by genes, and it may be possible to modulate pain perception through gene therapy.
| ALAMY

“Simple” and “clean” pain genes

Rememingly, the pain gene acts almost exclusively on this sodium channel and has little effect on the body’s other physiological activities.
This is a very rare condition in humans.
Generally speaking, genes that control one trait may also control other traits, and a particular trait may be controlled by multiple genes at the same time.
But there is a simple one-to-one relationship between the pain gene and the sodium channel, which makes it easier to implement gene therapy.

One of the researchers involved in the study said: “One of the most exciting aspects of this treatment is that it uses a gene with a very simple and well-defined phenotype, and this gene is at the heart of the body’s pain response.
It’s the perfect target for people with chronic pain.”

The researchers used CRISPR/Cas-9, the newly popular gene-editing tool, and traditional zinc finger protein to edit the pain gene in mice. They also used a series of techniques to prevent the effects of the gene editing from being maintained permanently.

The mice in the study had chronic pain, including inflammatory pain and neuropathic pain.
In addition, they were subjected to a series of thermal or tactile stimuli.
The results showed that the gene therapy not only made the mice much more tolerant to short-term pain, but also maintained long-term relief from chronic pain.

In the mouse model of pain perception, the pain perception of mice and rats was judged by their appearance (0, no expression;
1, moderate;
2, severe.)
| source: [2]

The future is bright, but the road is tortuous

Of course, the technology is still in its very early stages, and there are countless questions that need to be answered before it can be used.
For one thing, mice, after all, are not representative, and they may still experience pain differently from humans.
Second, even if no side effects have been reported, this fact remains to be confirmed.
For example, abnormalities in the sense of smell have been reported in humans with a mutation in the pain gene SCN9A, but much research remains to be done on whether it is as “simple” as scientists once thought.

In addition, one of the basic senses the body uses to understand the world would have to be more cautious if turning off the gene not only alleviates pain but also deprives the body of the ability to feel it.
Here is a 71-year-old Scottish woman who has a mutated pain gene that means she has never known pain and therefore cannot act on it.
On her hands, we could see numerous burn marks.

A 71-year-old woman with a genetic mutation that prevents her from feeling pain has burns all over her hands.
| Source: [3]

For all these reasons, it can be concluded that gene therapy is difficult to be applied to actual pain treatment in the short term, but as a new route different from traditional therapy, it still deserves our attention and encouragement.
In the future, the team aims to test the efficacy of the treatment in larger animals and even laboratory primates.

There is often such a plot in wuxia TV series: a man suddenly tells the main character, “Young man, look at your beautiful bones, you must be a wuxia wizard”…
From then on the protagonist began to the peak of life.
But for many people, osteoporosis is a worry ahead of bone cleanup.
Internet rumors of a variety of osteoporosis high incidence of people, osteoporosis self-examination symptoms and so on people worry, there is no lack of “drinking carbonated drinks will cause osteoporosis” such remarks.
Is such a claim true?
Today we are going to popularize science.

To understand the question “Does drinking soda cause osteoporosis?” we should first look at the causes of osteoporosis.
Dr. Zhong Kai, food safety doctor, once said that osteoporosis is nothing new, and there are many factors leading to osteoporosis, such as the peak of bone calcium, which is the base of the body;
Estrogen levels (especially in postmenopausal women);
Genetic factors;
Use medications, such as glucocorticoids;
Dietary calcium content;
Blood levels of vitamin D;
Exercise;
Bad habits such as smoking and drinking;
Organ diseases and so on.

There are many causes of osteoporosis, but there is no direct evidence of a link between osteoporosis and sodas.
So why do people raise the question, “Does drinking soda cause osteoporosis?”
This is mainly because of concerns about phosphorus in carbonated drinks, which is thought to affect calcium absorption and lead to osteoporosis.
But phosphorus itself is one of the essential nutrients to ensure bone health, and the amount of phosphorus in cola-type drinks is not high, about 17 milligrams per 100 milliliters of cola soda, and 172 milligrams per 100g of lean beef.

According to the Chinese Nutrition Society, an adult’s daily intake of phosphorus is 700 milligrams, the equivalent of about 12 330-milliliter cans of Coke.
Therefore, in a healthy adult, with adequate calcium intake, moderate consumption of soda will not directly lead to osteoporosis.

Seeing the above explanation, I believe we no longer have to worry about “drinking carbonated drinks can cause osteoporosis” such a question, after all, drinking cola does not affect our “bone” ah