Buy Avastin : Bevacizumab 400 mg/16 ml Injection Online

Description

Overview: Avastin is a medication manufactured by Roche Holding AG containing the active substance Bevacizumab. It is primarily used in the treatment of various types of cancer, including colorectal cancer, lung cancer, breast cancer, renal cell carcinoma, and glioblastoma multiforme. Avastin belongs to a class of medications called monoclonal antibodies, which work by targeting and inhibiting the activity of vascular endothelial growth factor (VEGF), a protein involved in tumor angiogenesis (the formation of new blood vessels to support tumor growth).

Active Substance:

• Bevacizumab: Avastin contains Bevacizumab, which is a monoclonal antibody that specifically targets and binds to vascular endothelial growth factor (VEGF). By binding to VEGF, Bevacizumab inhibits its interaction with VEGF receptors on the surface of endothelial cells, thereby blocking the signaling pathway involved in tumor angiogenesis. This inhibits the formation of new blood vessels within tumors, depriving them of the nutrients and oxygen they need to grow and metastasize.

Indications: Avastin (Bevacizumab) is primarily indicated for:

1. Colorectal Cancer: It is used in combination with chemotherapy as a first-line or subsequent treatment for metastatic colorectal cancer.
2. Lung Cancer: Avastin is indicated for the treatment of advanced non-small cell lung cancer (NSCLC) in combination with chemotherapy.
3. Breast Cancer: It is used in combination with chemotherapy for the treatment of metastatic breast cancer that is HER2-negative.
4. Renal Cell Carcinoma: Avastin is indicated in combination with interferon alfa for the treatment of metastatic renal cell carcinoma.
5. Glioblastoma Multiforme: It is used in combination with chemotherapy for the treatment of recurrent glioblastoma multiforme.

Mechanism of Action: Bevacizumab exerts its therapeutic effects by inhibiting the activity of vascular endothelial growth factor (VEGF), a key regulator of tumor angiogenesis. By binding to VEGF, Bevacizumab prevents its interaction with VEGF receptors on endothelial cells, inhibiting signaling pathways involved in the formation of new blood vessels. This reduces the blood supply to tumors, leading to decreased tumor growth, invasion, and metastasis.

Dosage and Administration: The dosage of Avastin (Bevacizumab) is determined by the healthcare provider based on the patient’s weight, medical condition, and type of cancer being treated. It is administered intravenously (into a vein) over a period of time specified by the prescribing healthcare provider. The recommended dosage and administration schedule may vary depending on the specific indication for which Avastin is being used and whether it is used as monotherapy or in combination with other cancer treatments.

Potential Side Effects: Common side effects associated with Avastin may include:

• Hypertension (high blood pressure)
• Proteinuria (presence of protein in the urine)
• Bleeding or clotting disorders
• Gastrointestinal perforation
• Wound healing complications
• Fatigue or weakness
• Nausea, vomiting, or diarrhea

Precautions:

• Avastin should be used with caution in patients with a history of cardiovascular disease, hypertension, bleeding disorders, or gastrointestinal perforation.
• It is contraindicated in pregnant women due to the potential risk of fetal harm.
• Patients should be monitored regularly for signs of hypertension, proteinuria, bleeding, or other adverse effects during treatment with Avastin.
• Avastin may interact with other medications, including anticoagulants, antiplatelet agents, and nonsteroidal anti-inflammatory drugs (NSAIDs), increasing the risk of bleeding.

In conclusion, Avastin (Bevacizumab) 400 mg/16 ml Injection contains the active substance Bevacizumab, a monoclonal antibody used in the treatment of various types of cancer. By targeting vascular endothelial growth factor (VEGF), Avastin inhibits tumor angiogenesis and reduces tumor growth and metastasis. While effective in cancer treatment, Avastin may cause side effects and should be used cautiously under medical supervision.