Description
Description:
Boletraaz is a medication containing the active substance everolimus. It belongs to a class of drugs known as mammalian target of rapamycin (mTOR) inhibitors. Everolimus is primarily used as an immunosuppressant to prevent rejection in organ transplant recipients and as an antineoplastic agent to treat various types of cancer.
Key Points:
- Active Ingredient:
- Everolimus: A derivative of rapamycin, everolimus inhibits the activity of mTOR, a protein kinase involved in cell growth, proliferation, and survival. By blocking mTOR signaling, everolimus interferes with cancer cell growth and angiogenesis, as well as immune cell activation and proliferation.
- Indications:
- Boletraaz is indicated for the treatment of various types of cancer, including advanced renal cell carcinoma, pancreatic neuroendocrine tumors, hormone receptor-positive breast cancer, and subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC). It is also used as an immunosuppressant to prevent organ rejection in kidney, liver, and heart transplant recipients.
- Mechanism of Action:
- Everolimus inhibits the activity of mTOR, a serine/threonine protein kinase that regulates cell growth, proliferation, and survival by integrating signals from growth factors, nutrients, and cellular energy status. By blocking mTOR signaling, everolimus interferes with cancer cell proliferation and survival, as well as immune cell activation and function.
- Dosage Form:
- Boletraaz is available as oral tablets, typically supplied in blister packs containing a specific number of tablets, each containing 10mg of everolimus.
- Dosage and Administration:
- The dosage of Boletraaz varies depending on the type of cancer being treated and other individual factors such as the patient’s age, weight, and renal function. It is usually taken orally once daily, with or without food, as prescribed by a healthcare provider.
- Precautions:
- Boletraaz should be used with caution in patients with hepatic or renal impairment, as well as in individuals with a history of infections, interstitial lung disease, or metabolic disorders. Regular monitoring of blood counts, renal function, liver function, and lipid levels is necessary during treatment with everolimus.
- Possible Side Effects:
- Common side effects of everolimus may include stomatitis, rash, fatigue, diarrhea, nausea, and peripheral edema. Serious adverse reactions such as infections, pneumonitis, renal failure, and metabolic abnormalities may occur and require prompt medical attention.
- Manufacturer:
- Boletraaz is manufactured by Alkem Laboratories Ltd., a leading pharmaceutical company known for its high-quality medications and commitment to patient care.
Note: Boletraaz is a valuable treatment option for patients with various types of cancer and transplant recipients requiring immunosuppression. It is important for patients to receive comprehensive counseling and regular medical monitoring during treatment with Boletraaz to manage potential side effects and optimize treatment outcomes. Patients should be educated about the importance of adherence to prescribed dosing regimens and the need for close communication with healthcare providers regarding any concerns or changes in their condition.
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