Description
Description:
EXFORGE 10 mg/160 mg is a medication formulated with two active substances: amlodipine and valsartan. It is used primarily for the treatment of hypertension (high blood pressure) in adult patients whose blood pressure is not adequately controlled with monotherapy.
Key Points:
- Active Ingredients:
- Amlodipine: Amlodipine is a calcium channel blocker that works by inhibiting the influx of calcium ions into vascular smooth muscle cells, leading to vasodilation and consequent reduction in blood pressure. It is effective in treating hypertension and angina.
- Valsartan: Valsartan is an angiotensin II receptor blocker (ARB) that blocks the binding of angiotensin II to its receptors, leading to vasodilation and decreased aldosterone secretion. This results in lowered blood pressure.
- Indications:
- EXFORGE 10 mg/160 mg is indicated for the treatment of hypertension in adult patients whose blood pressure is not adequately controlled with amlodipine or valsartan monotherapy. It is often prescribed as a combination therapy to achieve better blood pressure control.
- Mechanism of Action:
- Amlodipine and valsartan work through different mechanisms to lower blood pressure. Amlodipine inhibits calcium influx into vascular smooth muscle cells, leading to vasodilation, while valsartan blocks the effects of angiotensin II, resulting in vasodilation and decreased aldosterone secretion.
- Dosage Form:
- EXFORGE 10 mg/160 mg is available as oral tablets, typically supplied in blister packs containing 28 pills, each containing a fixed combination of 10 mg of amlodipine and 160 mg of valsartan.
- Dosage and Administration:
- The recommended dosage of EXFORGE 10 mg/160 mg is one tablet taken orally once daily. It can be taken with or without food. The dosage may be adjusted based on the individual patient’s response to treatment and tolerability.
- Precautions:
- EXFORGE 10 mg/160 mg should be used with caution in patients with severe hepatic impairment, renal impairment, or heart failure. Blood pressure, renal function, and electrolytes should be monitored regularly during treatment.
- Possible Side Effects:
- Common side effects of EXFORGE 10 mg/160 mg may include dizziness, peripheral edema, headache, flushing, and fatigue. Less common but more serious side effects such as hypotension, hyperkalemia, and renal impairment may occur and require medical attention.
- Manufacturer:
- EXFORGE 10 mg/160 mg is manufactured by Novartis, a leading pharmaceutical company known for its high-quality medications and commitment to patient care.
Note: EXFORGE 10 mg/160 mg offers an effective combination therapy option for patients with hypertension who require additional blood pressure control beyond what is achieved with monotherapy. It is important for patients to adhere to prescribed dosing regimens and to undergo regular medical monitoring to ensure optimal blood pressure management and to minimize the risk of adverse effects. Patients should be educated about the potential risks and benefits of EXFORGE 10 mg/160 mg therapy and encouraged to communicate any concerns or changes in their condition to their healthcare provider.
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