Description
Product Overview: Geftistar, manufactured by Lupin Pharmaceuticals Ltd., is a potent medication containing 250 mg of gefitinib per tablet. Each pack contains 100 tablets, offering a comprehensive and effective treatment option for patients diagnosed with certain types of cancer, particularly non-small cell lung cancer (NSCLC) with specific genetic mutations.
Active Substance: Gefitinib: Gefitinib is a tyrosine kinase inhibitor (TKI) that targets and inhibits the epidermal growth factor receptor (EGFR) pathway. By blocking EGFR signaling, gefitinib helps suppress tumor growth and proliferation in cancer cells that are dependent on this pathway for survival.
Mechanism of Action: Geftistar exerts its anti-cancer effects by selectively inhibiting the activity of EGFR tyrosine kinase, which plays a crucial role in promoting cell growth, survival, and angiogenesis in cancer cells. By blocking EGFR signaling, gefitinib helps induce apoptosis (cell death) and inhibit the proliferation of cancer cells, thereby slowing down tumor progression.
Clinical Applications: Geftistar is primarily used for the treatment of:
- Non-Small Cell Lung Cancer (NSCLC): Geftistar is indicated for the first-line treatment of patients with metastatic NSCLC that harbors specific EGFR mutations, such as exon 19 deletions or exon 21 (L858R) substitution mutations. It is also used in patients who have progressed on or after chemotherapy regimens.
Administration and Dosage: Geftistar is administered orally, typically once daily, with or without food. The recommended dosage is 250 mg per day, although dosage adjustments may be made based on individual patient factors such as tolerance and response to treatment. It is essential to adhere to the prescribed dosage regimen and to follow the guidance of a healthcare professional experienced in the management of cancer.
Manufacturer: Geftistar is manufactured by Lupin Pharmaceuticals Ltd., a leading global pharmaceutical company known for its commitment to quality and innovation in the field of oncology. Lupin Pharmaceuticals products undergo rigorous testing and adhere to stringent manufacturing standards to ensure safety, efficacy, and consistency.
Considerations and Side Effects: While generally well-tolerated, Geftistar may cause certain side effects in some individuals, including:
- Skin rash or acne-like rash
- Diarrhea
- Liver enzyme abnormalities
- Interstitial lung disease (rare but serious)
Patients should be closely monitored for signs of adverse reactions during treatment with Geftistar, and appropriate supportive care measures should be provided as needed.
Conclusion: Geftistar from Lupin Pharmaceuticals Ltd. offers a valuable treatment option for patients diagnosed with non-small cell lung cancer harboring specific EGFR mutations. With its active substance gefitinib, Geftistar helps inhibit EGFR signaling and suppress tumor growth, providing patients with improved outcomes and quality of life. As with any cancer medication, it is crucial to use Geftistar as directed by a healthcare professional experienced in oncology and to be aware of potential side effects and complications.
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