Description
Glenza is a potent medication formulated with Enzalutamide, an active pharmaceutical ingredient renowned for its efficacy in treating advanced prostate cancer. Manufactured by Glenmark (Onkos) Pharmaceuticals Ltd., Glenza comes in capsule form and is designed to target specific receptors involved in prostate cancer progression.
Composition: Each pack of Glenza contains 112 capsules, with each capsule containing 40 mg of Enzalutamide, alongside appropriate excipients.
Mechanism of Action: Enzalutamide, the key component of Glenza, functions by competitively inhibiting the binding of androgens to the androgen receptor (AR). By doing so, it inhibits AR nuclear translocation, DNA binding, and co-factor recruitment, thereby impeding prostate cancer cell growth and survival.
Indications: Glenza is indicated for the treatment of:
- Metastatic castration-resistant prostate cancer (mCRPC)
- Non-metastatic castration-resistant prostate cancer (nmCRPC)
- Metastatic hormone-sensitive prostate cancer (mHSPC)
Dosage and Administration: Glenza capsules should be administered orally, as directed by a qualified healthcare professional experienced in the management of prostate cancer. The recommended dose is usually 160 mg (four 40 mg capsules) once daily.
Precautions and Warnings:
- Glenza is contraindicated in patients with a history of hypersensitivity reactions to Enzalutamide or any of the excipients.
- Patients should be monitored regularly for signs of seizure activity, as Enzalutamide has been associated with an increased risk of seizures.
- Caution should be exercised when prescribing Glenza to patients with a history of cardiovascular disease or those at risk for cardiovascular events.
Side Effects: Common side effects associated with Glenza may include:
- Fatigue
- Hot flashes
- Hypertension
- Diarrhea
- Nausea
- Headache
- Decreased appetite
- Musculoskeletal pain
Storage: Glenza capsules should be stored at room temperature (25°C / 77°F) in a dry place away from direct sunlight. They should be kept out of reach of children and pets.
Disclaimer: The information provided above is for informational purposes only and should not be construed as medical advice. Patients should consult their healthcare provider for personalized guidance regarding the use of Glenza or any other medication.
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