Buy Kryxana : Ribociclib 200 mg Tablet 21’S Online

Description

Description: Kryxana is a medication manufactured by Novartis AG. It is available in tablet form, with each tablet containing 200 mg of the active ingredient Ribociclib. Ribociclib is a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor used in the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer.

Active Ingredient:

• Ribociclib: Ribociclib is an orally administered selective inhibitor of CDK4 and CDK6, which are proteins involved in regulating cell cycle progression. By inhibiting CDK4/6, Ribociclib blocks the phosphorylation of retinoblastoma protein (Rb), leading to cell cycle arrest and inhibition of tumor cell proliferation.

Manufacturer:

• Novartis AG: Novartis AG is the pharmaceutical company responsible for manufacturing Kryxana. It is a leading global healthcare company known for its innovative medicines and commitment to improving patient outcomes in various therapeutic areas, including oncology.

Uses: Kryxana (Ribociclib 200 mg Tablet) is primarily prescribed for the following purposes:

1. Breast Cancer Treatment: It is used in combination with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with HR+, HER2- advanced or metastatic breast cancer.
2. Advanced or Metastatic Breast Cancer: Ribociclib may also be used in combination with fulvestrant for the treatment of HR+, HER2- advanced or metastatic breast cancer in women with disease progression after endocrine therapy.

How to Use: Kryxana tablets are taken orally, usually once daily, with or without food. The tablets should be swallowed whole with a glass of water and should not be crushed, chewed, or split. The dosage and duration of treatment depend on various factors, including the patient’s medical condition, disease stage, and response to treatment. It is important to follow the prescribing healthcare provider’s instructions carefully.

Storage Conditions: Kryxana tablets should be stored at room temperature, away from moisture, heat, and direct sunlight. It is essential to keep the medication out of reach of children and pets. Proper storage helps maintain the stability and effectiveness of the tablets.

Mechanism of Action: Ribociclib works by selectively inhibiting CDK4/6, which are proteins involved in regulating cell cycle progression from the G1 phase to the S phase. By blocking CDK4/6 activity, Ribociclib prevents the phosphorylation of Rb protein, leading to cell cycle arrest and inhibition of tumor cell proliferation in HR+, HER2- breast cancer cells.

Precautions:

• Kryxana should be used with caution in patients with a history of liver impairment, QT interval prolongation, or certain medical conditions. Regular monitoring of liver function tests, electrocardiograms (ECGs), and blood counts may be required during treatment with Ribociclib.
• Female patients of reproductive potential should use effective contraception during treatment with Kryxana, as Ribociclib may cause fetal harm if used during pregnancy.

Contraindications: Kryxana (Ribociclib) is contraindicated in pregnant women, as well as in individuals with a known hypersensitivity to Ribociclib or any component of the formulation. It should not be used concurrently with strong CYP3A4 inducers or inhibitors.

Drug Interactions: Ribociclib may interact with certain medications, including strong CYP3A4 inducers, inhibitors, and substrates. Patients should inform their healthcare provider about all medications they are taking to avoid potential interactions.

Side Effects: Common side effects of Kryxana may include neutropenia, leukopenia, fatigue, nausea, diarrhea, alopecia (hair loss), and vomiting. Other potential side effects include QT interval prolongation, hepatotoxicity, and thrombocytopenia. Serious adverse reactions such as infections, cardiac events, and interstitial lung disease may occur but are rare.

Patients should consult their healthcare provider for personalized advice and information regarding Kryxana (Ribociclib 200 mg Tablet), including its uses, dosage, and potential side effects.