Description
Lupkynis (voclosporin) is a medication used to treat adult patients with active lupus nephritis, a type of autoimmune disease that affects the kidneys. It is a calcineurin inhibitor that suppresses the immune system and is administered orally.
Uses:
Lupkynis is used to treat adult patients with active lupus nephritis, a condition that can lead to damage and failure of the kidneys. Lupus nephritis is a type of autoimmune disease in which the immune system attacks the kidneys, causing inflammation and damage. Lupkynis works by suppressing the immune system and reducing inflammation in the kidneys.
Storage Conditions:
Lupkynis should be stored at room temperature below 86°F (30°C) in its original container. The medication should be protected from light and moisture.
Mechanism of Action:
Lupkynis works by inhibiting calcineurin, an enzyme that plays a role in the activation of T-cells in the immune system. By inhibiting calcineurin, Lupkynis suppresses the activity of the immune system and reduces inflammation in the kidneys in patients with lupus nephritis.
How to Use:
Lupkynis is taken orally twice daily with food. The dosage and duration of treatment are determined by the healthcare provider based on the patient’s weight and kidney function. The recommended starting dose is 23.7 mg twice daily.
Precautions:
Before taking Lupkynis, patients should inform their healthcare provider of any allergies, medical conditions, and medications they are currently taking. Lupkynis may increase the risk of infections and certain types of cancer, and patients should be monitored for signs of infection and regularly screened for cancer. Lupkynis may also cause an increase in blood pressure and kidney function tests should be performed regularly to monitor for changes.
Drug Interactions:
Lupkynis may interact with drugs that affect the immune system or are metabolized by the liver. Patients should inform their healthcare provider of any medications they are taking, including over-the-counter medications, vitamins, and supplements, before taking Lupkynis.
Contraindications:
Lupkynis is contraindicated in patients with a known hypersensitivity to voclosporin or any of its components. It should not be used in patients with liver impairment, in combination with certain medications, or during pregnancy.
Overdose:
In the event of an overdose, patients should contact their healthcare provider. Symptoms of an overdose may include headaches, tremors, confusion, and seizures.
Adverse Reactions:
The most common adverse reactions reported with Lupkynis include diarrhea, headache, nausea, and hypertension. Patients should report any adverse reactions to their healthcare provider.
Overall, Lupkynis is a calcineurin inhibitor medication used to treat adult patients with active lupus nephritis by suppressing the immune system and reducing inflammation in the kidneys. The medication is taken twice daily with food, and the dosage and duration of treatment are determined based on the patient’s weight and kidney function. Patients should inform their healthcare provider of any allergies, medical conditions, and medications they are taking and should be monitored regularly for signs of infection, cancer, and changes in blood pressure and kidney function. Lupkynis may cause adverse reactions such as diarrhea, headache, nausea, and hypertension.
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