Description
Nexletol is a prescription medication used to lower high levels of low-density lipoprotein (LDL) cholesterol in the blood. It is marketed under the brand name Nexletol and contains the active ingredient bempedoic acid.
Uses:
Nexletol is used to lower LDL cholesterol levels, which can lead to a reduced risk of heart disease and stroke. It is used in combination with other cholesterol-lowering medications or as a single therapy for patients who cannot tolerate statins.
Storage Conditions:
Nexletol should be stored at room temperature between 68°F to 77°F (20°C to 25°C) in its original container. It should be protected from light and moisture. The tablets should not be stored in the bathroom or near any sources of heat.
Mechanism of Action:
Bempedoic acid in Nexletol works by inhibiting a specific enzyme called ATP citrate lyase, which plays a critical role in the production of cholesterol in the liver. By blocking this enzyme, Nexletol reduces the amount of cholesterol produced by the liver. Over time, this leads to a decrease in LDL cholesterol levels in the blood.
HOW TO USE:
The patient should follow the instructions of their healthcare provider when using Nexletol. It can be taken with or without food. The tablet should be swallowed whole and should not be broken, crushed, or chewed. The dosage is based on the patient’s medical condition and response to treatment.
Precautions:
• Patients should inform their healthcare provider if they have liver disease, kidney disease, or any allergies to bempedoic acid or any other medications.
• Nexletol should not be used during pregnancy or breastfeeding.
• Patients should avoid drinking alcohol while taking Nexletol.
Drug Interactions:
• Nexletol may interact with other medications, such as statins, fibrates, or cyclosporine, which can increase the risk of side effects and decrease the effectiveness of the drug.
• Patients should not take Nexletol with other cholesterol-lowering medications without approval from their healthcare provider.
• Nexletol should not be taken with certain antibiotics, such as clarithromycin and erythromycin.
Contraindications:
• Nexletol should not be used in patients who have a known allergy to bempedoic acid or any of its components.
• It should not be used during pregnancy or breastfeeding.
• Nexletol should not be used in patients with severe liver disease.
Overdose:
An overdose of Nexletol can cause symptoms such as diarrhea, nausea, and vomiting. If an overdose is suspected, patients should seek emergency medical attention.
Adverse Reactions:
The most common side effects of Nexletol include upper respiratory tract infections, muscle pain, and diarrhea. Other potential side effects include back pain, abdominal pain, and headache. Patients should contact their healthcare provider if they experience any unusual symptoms while taking Nexletol.
In conclusion, Nexletol is a prescription medication used to lower high levels of LDL cholesterol in the blood. It contains the active ingredient bempedoic acid, which works by inhibiting an enzyme involved in cholesterol production in the liver. It is important to follow the instructions of the healthcare provider, monitor for side effects, and avoid certain medications and activities while taking Nexletol. Patients should also inform their healthcare provider of any allergies or medical conditions before taking Nexletol.
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