Description
Rukobia (fostemsavir) is an antiretroviral medication used in combination with other medications to treat HIV-1 infection in patients who have undergone extensive antiretroviral treatment and have multidrug-resistant HIV-1 infection. It belongs to the class of antiretroviral drugs known as attachment inhibitors.
Uses:
Rukobia is indicated for the treatment of HIV-1 infection in adult patients who have failed multiple antiretroviral therapy (ART) regimens due to resistance, intolerance, or safety considerations. It is used in combination with other ART medications.
Storage Conditions:
Rukobia should be stored at room temperature (20-25°C). It should be kept in its original container and should be protected from moisture and heat. It should not be frozen.
Mechanism of Action:
Rukobia works by blocking the attachment of the HIV-1 virus to the CD4+ T-cell receptor, which prevents the virus from entering and infecting the host cells. This slows the spread of the virus and reduces the risk of disease progression.
HOW TO USE:
Rukobia is given as a tablet which should be taken with or without food. The recommended dose is 600 mg twice daily. Patients should follow the dosing instructions provided by their healthcare provider and should not change their dosage or stop taking the medication without first consulting with a healthcare provider.
Precautions:
• Patients should be monitored for hypersensitivity reactions while taking Rukobia.
• Rukobia may interact with other medications that are metabolized by cytochrome P450 enzymes. Patients should inform their healthcare provider of all medications they are taking while using Rukobia.
• Patients with pre-existing hepatic or renal disease should be monitored closely while taking Rukobia.
Drug Interactions:
Rukobia may interact with other medications that are metabolized by cytochrome P450 enzymes. Patients should inform their healthcare provider of all medications they are taking while using Rukobia.
Contraindications:
Rukobia is contraindicated in patients with a known hypersensitivity to fostemsavir or any of the ingredients in the medication. It should also not be used in patients who are taking medications that are strong inducers of CYP3A4.
Overdose:
In the event of an overdose, patients should seek immediate medical attention. It is not known if there is a specific treatment for Rukobia overdose.
Adverse Reactions:
Common adverse reactions associated with the use of Rukobia include diarrhea, nausea, headache, and fatigue. Patients should contact their healthcare provider if they experience any unusual reactions while taking Rukobia.
In conclusion, Rukobia is an antiretroviral medication used to treat multidrug-resistant HIV-1 infection. It works by blocking the attachment of the HIV-1 virus to the CD4+ T-cell receptor. Patients should take the medication exactly as prescribed by a healthcare provider and should be monitored for hypersensitivity reactions. Drug interactions with cytochrome P450 metabolized medications should be monitored closely. Adverse reactions such as diarrhea, nausea, headache, and fatigue can occur, and patients should contact their healthcare provider if any unusual reactions occur. It is contraindicated in patients with a known hypersensitivity to fostemsavir or any of the ingredients in the medication and should not be used in patients who are taking medications that are strong inducers of CYP3A4.
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