Description
Skilarence (dimethyl fumarate) is a prescription medication used to treat adult patients with moderate to severe plaque psoriasis. It comes in the form of an oral capsule and works by reducing inflammation in the body.
Uses:
Skilarence is used to treat adult patients with moderate to severe plaque psoriasis. Psoriasis is a chronic autoimmune skin disorder that causes thick, scaly patches on the skin. These patches are often itchy and painful and can cause significant discomfort and embarrassment for patients.
Storage Conditions:
Skilarence should be stored at room temperature between 68°F and 77°F (20°C and 25°C) in a dry place. It should be kept out of reach of children and pets.
Mechanism of action:
The exact mechanism of action of Skilarence is not fully understood. However, it is believed that dimethyl fumarate works by activating a transcription factor called nuclear factor (erythroid-derived 2)-like 2 (Nrf2). This transcription factor regulates the expression of genes involved in the antioxidant response, which reduces inflammation in the body.
HOW TO USE:
Skilarence should be taken as directed by the prescribing physician. The usual starting dose is 30 mg twice daily for the first week. The dose can then be increased to 120 mg twice daily in the second week. Patients should be monitored for side effects during the first month of treatment and then periodically thereafter.
Precautions:
Skilarence should not be used in patients with a known hypersensitivity to dimethyl fumarate or any of its components. Patients should be monitored for signs of allergic reactions, such as itching, hives, or difficulty breathing. Skilarence may increase the risk of infections, so patients should avoid contact with individuals who have active infections.
Drug Interactions:
Skilarence may interact with other medications, so patients should inform their doctor or pharmacist if they are taking any other medications, including over-the-counter products, herbal supplements, and vitamins. Skilarence may interact with drugs that affect the immune system, such as cyclosporine and methotrexate.
Contraindications:
Skilarence is contraindicated in patients with a history of progressive multifocal leukoencephalopathy (PML), a rare viral infection of the brain. It is also contraindicated in patients with severe renal impairment or hepatic impairment.
Overdose:
In the event of an overdose of Skilarence, patients should seek immediate medical attention. Symptoms of an overdose may include nausea, vomiting, diarrhea, and abdominal pain.
Adverse Reactions:
Common adverse reactions associated with Skilarence include flushing, abdominal pain, diarrhea, and nausea. These side effects usually subside over time as patients continue with treatment. However, if these side effects persist or worsen, patients should seek medical attention.
In summary, Skilarence is an effective medication in the treatment of adult patients with moderate to severe plaque psoriasis. It works by reducing inflammation in the body and should be used as directed by the prescribing physician. However, patients should be aware of the potential side effects and should seek medical attention if these symptoms persist or worsen. Additionally, patients should be monitored for signs of hypersensitivity and should avoid contact with individuals who have active infections.
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