Description
Spinraza (Nusinersen) is a prescription medication used to treat Spinal Muscular Atrophy (SMA), a genetic disease that affects the spinal cord and nerve cells that control muscles and movement. It is given by intrathecal injection into the spinal column.
Uses:
Spinraza is used to treat SMA in both adults and children. It works by increasing the production of a protein called SMN (Survival of Motor Neuron), which is essential for the health of motor neurons that control muscle movement. By fostering the production of SMN, Spinraza improves the function and survival of motor neurons, leading to improved muscle control and movement.
Storage Conditions:
Spinraza is a delicate medication and should be stored in a refrigerator between 2-8°C (36-46°F), protected from light. The medication should not be frozen, shaken, or vigorously agitated, as this can destabilize the drug.
Mechanism of Action:
Spinraza works by improving the expression of SMN protein, which is essential for the development and survival of motor neurons. SMN protein deficiency causes SMA, a neurodegenerative disease that leads to muscle weakness, atrophy, and loss of function. Spinraza fosters the production of SMN protein, which results in improved motor neuron function, muscle control, and movement.
HOW TO USE:
Spinraza is given by a healthcare professional in a hospital or clinic setting through a lumbar puncture or spinal tap. The medication is introduced directly into the cerebrospinal fluid that surrounds the spinal cord, where it can reach the motor neurons and begin to augment SMN protein expression. The injection is typically given every other week for the first four doses, followed by a maintenance dose every four months.
Precautions:
Individuals receiving Spinraza should inform their healthcare provider of any medical conditions they have, particularly bleeding disorders or spinal cord abnormalities. Individuals may experience post-procedural headaches; informing medical staff about any discomfort or pain experienced is advisable. It is also essential to notify healthcare providers of any prescription or non-prescription medications, supplements, or herbal remedies being taken before Spinraza treatment.
Drug Interactions:
No significant drug interaction studies have been completed with Spinraza. Nevertheless, it is advised to inform your medical provider of any medication, prescription or over-the-counter, herbal remedies, and supplements that you are taking before starting treatment with Spinraza.
Contraindications:
Spinraza is contraindicated individuals who have received a procedure such as a lumbar puncture or spinal tap where bleeding occurred. Also, it is not advised for individuals with a history of allergic reactions to the drug.
Overdose:
Currently, there is no established protocol for overdose of Spinraza.
Adverse Reactions:
Common side effects of Spinraza include postoperative headaches, nausea, and vomiting. Other side effects may include low blood pressure, urine retention, bowel problems, and respiratory infections. Serious side effects, such as spinal fluid leaks, should be promptly reported to medical staff.
In conclusion, Spinraza is an intrathecal injection used to treat SMA by increasing the production of the SMN protein, promoting the survival and health of motor neurons. The medication should be stored in the refrigerator and administered by a healthcare professional. Individuals taking Spinraza should inform their medical provider about any bleeding or spinal cord abnormalities, as well as any prescription or non-prescription medications, supplements, or herbal remedies that they are taking. The drug is contraindicated for people who have had previous procedures involving bleeding and for those who have experienced allergic reactions in the past. Appropriate precautions and monitoring should be taken to minimize adverse reactions.
Reviews
There are no reviews yet.