Buy Synthivan : Atazanavir & Ritonavir Tablet 30’S Online

Description

Synthivan is a combination medication containing two active substances: Atazanavir and Ritonavir. It is primarily used in the treatment of HIV (human immunodeficiency virus) infection, particularly in patients with multidrug-resistant strains or those who have not responded to other antiretroviral therapies. Synthivan is formulated to improve the efficacy and tolerability of treatment by combining two antiretroviral agents with complementary mechanisms of action.

Key Points:

• Active Ingredients:
  • Atazanavir: Atazanavir is a protease inhibitor that works by inhibiting the activity of the HIV protease enzyme, which is essential for the replication of the virus. By blocking protease activity, atazanavir prevents the cleavage of viral polyproteins, thereby inhibiting the production of mature infectious virions.
  • Ritonavir: Ritonavir is a potent inhibitor of cytochrome P450 3A4 (CYP3A4), an enzyme involved in the metabolism of various drugs, including protease inhibitors. When used in combination with other protease inhibitors such as atazanavir, ritonavir functions as a pharmacokinetic enhancer, increasing the plasma concentrations and half-life of the co-administered drug.
• Indications:
  • Synthivan is indicated for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 15 kg. It is typically used as part of combination antiretroviral therapy (ART) regimens to achieve viral suppression and improve immune function in HIV-infected individuals.
• Mechanism of Action:
  • Atazanavir and ritonavir work synergistically to inhibit HIV replication by blocking different stages of the viral life cycle. Atazanavir inhibits the activity of the HIV protease enzyme, preventing the production of mature infectious virions, while ritonavir enhances the plasma concentrations of atazanavir by inhibiting its metabolism.
• Dosage and Administration:
  • The recommended dosage of Synthivan may vary depending on individual patient factors, including previous treatment history, viral load, and drug tolerability. It is usually taken orally once daily with food to enhance absorption and minimize gastrointestinal side effects. The tablets should be swallowed whole with water and not chewed or crushed.
• Precautions:
  • Synthivan should be used with caution in patients with hepatic impairment, as both atazanavir and ritonavir are extensively metabolized in the liver. Regular monitoring of liver function tests is recommended during treatment to detect any signs of hepatotoxicity or liver dysfunction.
• Possible Side Effects:
  • Common side effects of Synthivan may include gastrointestinal disturbances (nausea, vomiting, diarrhea), hyperbilirubinemia (elevated bilirubin levels), rash, headache, and fatigue. Less common but more serious side effects such as hepatotoxicity, pancreatitis, and immune reconstitution syndrome (IRS) may occur and require medical attention.
• Manufacturer:
  • Synthivan is manufactured by Cipla Ltd., a leading pharmaceutical company known for its expertise in HIV/AIDS therapeutics and its commitment to providing affordable and accessible treatment options for patients worldwide.

Note: Synthivan offers a convenient and effective treatment option for patients with HIV infection, providing dual antiretroviral therapy in a single tablet formulation. It is important for patients to adhere to prescribed dosing regimens and undergo regular medical monitoring to ensure optimal viral suppression and to minimize the risk of treatment-related adverse effects. Patients should be educated about the importance of lifelong antiretroviral therapy and the need for consistent follow-up care to manage their HIV infection effectively.