Description
Description: Taspiance is an injectable medication manufactured by Emcure Pharmaceuticals Ltd. Each injection contains Peginterferon alfa-2a in a strength of 180 mcg per 0.5 ml. Peginterferon alfa-2a is a form of interferon that is pegylated for extended duration of action, primarily used in the treatment of chronic viral infections such as hepatitis B and hepatitis C.
Active Ingredient:
- Peginterferon alfa-2a: Peginterferon alfa-2a is a synthetic form of interferon alfa-2a, a naturally occurring protein in the body that plays a key role in the immune response against viral infections. Pegylation prolongs the half-life of interferon alfa-2a, allowing for less frequent dosing and improved patient compliance.
Manufacturer:
- Emcure Pharmaceuticals Ltd.: Emcure Pharmaceuticals Ltd. is the pharmaceutical company responsible for manufacturing Taspiance. Emcure is a leading global pharmaceutical company known for its high-quality medicines and commitment to healthcare innovation.
Uses: Taspiance (Peginterferon alfa-2a 180 mcg Injection) is primarily prescribed for the following purposes:
- Hepatitis B Treatment: It is used in the treatment of chronic hepatitis B infection, either alone or in combination with other antiviral medications, to suppress viral replication and reduce liver inflammation.
- Hepatitis C Treatment: Peginterferon alfa-2a is also used in combination with ribavirin or direct-acting antiviral agents (DAAs) for the treatment of chronic hepatitis C infection, aiming to achieve sustained virologic response (SVR) and prevent liver damage.
Strength:
- Each injection of Taspiance contains Peginterferon alfa-2a with a strength of 180 mcg per 0.5 ml. This standardized dosage ensures accurate dosing and optimal therapeutic efficacy.
How to Use: Taspiance injections are administered subcutaneously (under the skin) by a healthcare professional. The dosage and duration of treatment may vary depending on the patient’s medical condition, viral genotype, and treatment response. It is important to follow the prescribing healthcare provider’s instructions carefully.
Storage Conditions: Taspiance injections should be stored as per the manufacturer’s instructions, typically at room temperature, away from moisture, heat, and direct sunlight. Proper storage helps maintain the stability and effectiveness of the medication.
Mechanism of Action: Peginterferon alfa-2a exerts its antiviral effects by modulating the body’s immune response to viral infections. It stimulates the activity of certain immune cells, such as natural killer cells and T lymphocytes, which target and destroy virus-infected cells. Additionally, Pegylation prolongs the half-life of interferon alfa-2a, allowing for sustained antiviral activity.
Precautions:
- Taspiance should be used with caution in patients with a history of psychiatric disorders, autoimmune diseases, or severe cardiac or renal impairment. Regular monitoring of liver function tests, thyroid function tests, and blood counts may be required during treatment.
- Patients should be counseled about the potential side effects of Peginterferon alfa-2a, including flu-like symptoms, depression, and hematological abnormalities.
Contraindications: Taspiance (Peginterferon alfa-2a) is contraindicated in individuals with known hypersensitivity to interferons or any component of the formulation. It should not be used in patients with decompensated liver disease, severe autoimmune disorders, or uncontrolled psychiatric illness.
Drug Interactions: Peginterferon alfa-2a may interact with certain medications, including immunosuppressants, antiretroviral agents, and antidepressants. Patients should inform their healthcare provider about all medications they are taking to avoid potential interactions.
Side Effects: Common side effects of Taspiance may include flu-like symptoms (such as fever, chills, and fatigue), myelosuppression (such as neutropenia and thrombocytopenia), injection site reactions, and psychiatric disorders (such as depression and anxiety). Other potential side effects include thyroid dysfunction, autoimmune reactions, and hepatotoxicity. Serious adverse reactions such as severe depression, suicidal ideation, and hepatic decompensation may occur but are rare.
Patients should consult their healthcare provider for personalized advice and information regarding Taspiance (Peginterferon alfa-2a 180 mcg Injection), including its uses, dosage, and potential side effects.
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