Description
Voxzogo is a synthetic copy of a naturally occurring protein called C-type natriuretic peptide (CNP). It is used to treat achondroplasia, a genetic disorder that causes short stature and limb abnormalities.
Uses:
Voxzogo is used to treat achondroplasia in children aged 2 through 17 years who have open epiphyses, to help increase their growth rate and improve their adult height. Achondroplasia is a genetic disorder that causes bones to grow abnormally, leading to short stature, bowed legs, and other skeletal abnormalities.
Storage Conditions:
Voxzogo should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C) and protected from light. The medication should not be frozen or shaken.
Mechanism of Action:
Voxzogo works by mimicking the effects of CNP, a protein that is involved in the regulation of bone growth. CNP helps to decrease the activity of a protein called fibroblast growth factor receptor 3 (FGFR3) that is responsible for slowing bone growth in people with achondroplasia. Voxzogo helps to increase growth rate, improve bone growth, and ultimately improve adult height in patients with achondroplasia.
HOW TO USE:
Voxzogo should be administered by subcutaneous injection once a day. The dosage is based on the patient’s weight and should be determined by the healthcare provider. The injection should be given by a healthcare professional or the patient’s caregiver who has been appropriately trained. Patients should not inject themselves unless instructed by the healthcare provider.
Precautions:
• Patients with known hypersensitivity to the medication or any of its components should not be treated with Voxzogo.
• Voxzogo should be used with caution in patients with a history of hypotension, heart failure, or other cardiovascular conditions.
• Patients should be monitored for signs of allergic reactions, including rash, itching, difficulty breathing, or swelling of the hands, face, or tongue.
Drug Interactions:
• There are no known drug interactions with Voxzogo.
Contraindications:
• Voxzogo should not be used in patients who are allergic to the medication or any of its components.
• Voxzogo is contraindicated in patients with closed epiphyses.
Overdose:
There is limited information on the effects of overdose with Voxzogo. In case of overdose, patients should seek immediate medical attention.
Adverse Reactions:
The most common adverse reactions to Voxzogo include injection site reactions, such as redness, swelling, or pain, headache, and gastrointestinal symptoms, such as nausea and vomiting. Patients should notify their healthcare provider if they experience any unusual symptoms while taking Voxzogo.
In summary, Voxzogo is a medication used to treat achondroplasia, a genetic disorder that causes short stature and limb abnormalities. It works by mimicking the effects of the naturally occurring protein CNP, which regulates bone growth and decreases the activity of the FGFR3 protein that slows bone growth in patients with achondroplasia. Voxzogo should be administered by subcutaneous injection once a day and dosed based on the patient’s weight. Patients with known hypersensitivity to the medication or any cardiovascular conditions should use Voxzogo with caution. The medication is contraindicated in patients with closed epiphyses. Adverse reactions include injection site reactions, headache, and gastrointestinal symptoms. The medication should be stored in the refrigerator and protected from light. Patients should contact their healthcare provider if they experience any unusual symptoms while taking Voxzogo.
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