Description
Description: X-Trant is a medication manufactured by Natco Pharma Ltd. It is available in capsule form, with each capsule containing 140 mg of the active ingredient Estramustine. Estramustine is a unique combination of an estrogen derivative (estrogen) and a nitrogen mustard derivative (mustine) and is primarily used in the treatment of metastatic prostate cancer.
Active Ingredient:
- Estramustine: Estramustine is a prodrug that combines the actions of estrogen and nitrogen mustard. Estrogen inhibits the production of testosterone, a hormone that stimulates the growth of prostate cancer cells, while nitrogen mustard acts as an alkylating agent, damaging the DNA of cancer cells and inhibiting their proliferation.
Manufacturer:
- Natco Pharma Ltd.: Natco Pharma Ltd. is the pharmaceutical company responsible for manufacturing X-Trant. It is a leading global pharmaceutical company known for its high-quality generic medications and commitment to providing affordable healthcare solutions.
Uses: X-Trant (Estramustine 140 Mg Capsules) is primarily prescribed for the following purposes:
- Prostate Cancer Treatment: It is used in the treatment of metastatic prostate cancer, particularly in patients who have failed initial hormone therapy or who are not candidates for surgical castration.
How to Use: X-Trant capsules are taken orally, usually in divided doses throughout the day. The capsules should be swallowed whole with a glass of water and should not be crushed or chewed. The dosage and duration of treatment depend on various factors, including the patient’s medical condition, disease stage, and response to treatment. It is important to follow the prescribing healthcare provider’s instructions carefully.
Storage Conditions: X-Trant capsules should be stored at room temperature, away from moisture, heat, and direct sunlight. It is essential to keep the medication out of reach of children and pets. Proper storage helps maintain the stability and effectiveness of the capsules.
Mechanism of Action: Estramustine exerts its anticancer effects through a combination of estrogenic and alkylating actions. Estrogen inhibits the production of testosterone, which is essential for the growth of prostate cancer cells, while nitrogen mustard damages the DNA of cancer cells, leading to cell death and inhibition of tumor growth.
Precautions:
- X-Trant should be used with caution in patients with a history of cardiovascular disease, liver impairment, or certain medical conditions. Regular monitoring of liver function tests and blood counts may be required during treatment with Estramustine.
- Female patients of reproductive potential should avoid using X-Trant, as it may cause harm to a developing fetus if used during pregnancy.
Contraindications: X-Trant (Estramustine) is contraindicated in pregnant women, as well as in individuals with a known hypersensitivity to Estramustine or any component of the formulation. It should not be used concurrently with other estrogen-containing medications.
Drug Interactions: Estramustine may interact with certain medications, including anticoagulants, corticosteroids, and other hormonal therapies. Patients should inform their healthcare provider about all medications they are taking to avoid potential interactions.
Side Effects: Common side effects of X-Trant may include nausea, vomiting, diarrhea, fatigue, fluid retention, and breast tenderness. Other potential side effects include thromboembolic events, hepatic dysfunction, and allergic reactions. Serious adverse reactions such as myelosuppression and cardiovascular events may occur but are rare.
Patients should consult their healthcare provider for personalized advice and information regarding X-Trant (Estramustine 140 Mg Capsules), including its uses, dosage, and potential side effects.
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