Description
Description: XENICAL 120mg hard capsules, manufactured by Roche, contain orlistat as the active substance. Each box includes 84 capsules, each containing 120 milligrams of orlistat. XENICAL is used as a weight loss aid for the treatment of obesity in adults, in conjunction with a reduced-calorie diet.
Active Substance: Orlistat is a potent, reversible inhibitor of gastrointestinal lipases. It works by blocking the absorption of dietary fats, thereby reducing caloric intake and aiding in weight loss.
Indications: XENICAL 120mg is indicated for weight loss in obese patients with a body mass index (BMI) of 30 or higher, or overweight patients with a BMI of 27 or higher who have associated risk factors such as hypertension, diabetes, or dyslipidemia.
Mechanism of Action:
- Orlistat works locally in the gastrointestinal tract by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases.
- By inhibiting these enzymes, orlistat prevents the hydrolysis of triglycerides into absorbable free fatty acids and monoglycerides.
- This inhibition reduces the absorption of dietary fats by approximately 30%, resulting in decreased caloric intake and weight loss.
Administration:
- XENICAL 120mg capsules are administered orally.
- The recommended dose is one 120 mg capsule taken with water three times a day with each main meal containing fat (during or up to one hour after the meal).
- If a meal is missed or contains no fat, the dose can be omitted.
- Patients should adhere to a nutritionally balanced, reduced-calorie diet that contains approximately 30% of calories from fat, and the diet should be rich in fruits and vegetables.
Monitoring:
- Regular monitoring of weight loss and dietary adherence is recommended.
- Periodic assessments of overall health and any potential gastrointestinal side effects should be conducted.
Side Effects: Common side effects associated with the use of XENICAL may include:
- Gastrointestinal issues (e.g., oily or fatty stools, flatus with discharge, increased defecation, fecal urgency)
- Abdominal pain or discomfort
- Headache
Serious but rare side effects may include:
- Severe liver injury (patients should report symptoms like jaundice, itching, or dark urine)
- Kidney stones
- Oxalate nephropathy
Precautions:
- XENICAL should be used with caution in patients with chronic malabsorption syndrome or cholestasis.
- It is important to inform the healthcare provider about all medications, including over-the-counter drugs and herbal supplements, as they may interact with orlistat.
- Patients should take a multivitamin supplement at bedtime or at least two hours after the administration of XENICAL, as orlistat can reduce the absorption of fat-soluble vitamins (A, D, E, and K).
Consultation with Healthcare Professional:
- The use of XENICAL should be discussed with a qualified healthcare professional, typically a primary care physician or a specialist in weight management.
- A thorough medical evaluation should be conducted to determine the suitability of XENICAL for the patient and to discuss potential risks and benefits before starting therapy.
XENICAL 120mg hard capsules by Roche provide an effective solution for weight loss and obesity management when used alongside a reduced-calorie diet. Proper adherence to dosage, dietary guidelines, and monitoring ensures maximum efficacy and safety.
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