Description
Description: Xgeva is an injectable medication containing the active ingredient Denosumab, available in a strength of 120 mg per 1.7 mL injection. Manufactured by Amgen Pharmaceuticals Ltd. and marketed by GlaxoSmithKline Pharmaceuticals Ltd., Xgeva is used in the treatment of certain bone-related conditions, particularly in patients with cancer that has spread to the bones.
Medical Uses: Xgeva (Denosumab) is indicated for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. It is also used to treat bone loss associated with certain types of cancer, such as prostate cancer, breast cancer, and multiple myeloma. Denosumab works by inhibiting the activity of a protein called RANK ligand (RANKL), which is involved in the breakdown of bone tissue. By blocking RANKL, Xgeva helps reduce the risk of fractures, spinal cord compression, and other skeletal complications in patients with bone metastases.
Administration: Xgeva is administered as a subcutaneous injection, typically once every four weeks, by a healthcare professional. The dosage and frequency of administration may vary depending on factors such as the patient’s medical condition, response to treatment, and underlying cancer type. The injection is given into the upper arm, upper thigh, or abdomen, rotating injection sites with each dose.
Manufacturer: Xgeva is manufactured by Amgen Pharmaceuticals Ltd., a leading biotechnology company known for developing innovative therapies for various medical conditions. Amgen Pharmaceuticals Ltd. adheres to strict manufacturing standards to ensure the safety, efficacy, and reliability of their products.
Marketed by: Xgeva is marketed by GlaxoSmithKline Pharmaceuticals Ltd., a global pharmaceutical company committed to improving healthcare outcomes through research, innovation, and patient-centered solutions. GlaxoSmithKline Pharmaceuticals Ltd. collaborates with healthcare professionals and regulatory authorities to ensure access to quality medications for patients worldwide.
Storage: Xgeva injections should be stored according to the manufacturer’s instructions, typically at a controlled room temperature (between 20°C and 25°C) away from light and moisture. It is essential to keep the medication out of reach of children and pets. Patients should not use Xgeva injections beyond their expiration date.
Precautions:
- Xgeva should only be used under the supervision of a qualified healthcare professional experienced in the treatment of cancer-related bone conditions.
- Patients should undergo regular monitoring of calcium levels, kidney function, and other relevant laboratory parameters during treatment with Xgeva.
- Denosumab may increase the risk of osteonecrosis of the jaw (ONJ) and hypocalcemia, so patients should be educated on proper dental care and advised to report any symptoms such as jaw pain or numbness, loose teeth, or muscle spasms.
Side Effects: Common side effects of Xgeva may include:
- Fatigue
- Nausea
- Diarrhea
- Back pain
- Joint pain
- Muscle pain
- Headache
Serious side effects such as severe hypocalcemia, osteonecrosis of the jaw, and atypical femoral fractures are possible but less common. Patients should seek medical attention if they experience any severe or persistent side effects while receiving treatment with Xgeva.
Disclaimer: Xgeva injections should only be used under the supervision of a qualified healthcare professional and as part of a comprehensive treatment plan for cancer-related bone conditions. This description provides general information about the medication and its uses and should not replace medical advice from a healthcare provider.
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