Description
Zejula (niraparib) is an oral medication that falls under the class of drugs known as PARP (poly (ADP-ribose) polymerase) inhibitors. It is used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancers in adult patients.
Mechanism of Action:
Zejula works by blocking the activity of an enzyme called PARP. This enzyme helps to repair damaged DNA in cells. However, by blocking PARP, Zejula prevents cancer cells from repairing damaged DNA, leading to their death.
Uses:
Zejula is used to treat adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancers.
Storage Conditions:
Zejula should be stored at room temperature, away from heat and moisture. It should be kept in its original packaging until it is used.
HOW TO USE:
Zejula is taken orally, once daily, with or without food. The dosage and duration of treatment depend on the patient’s medical condition and response to therapy. Patients should swallow the capsule whole and not crush or chew it.
Precautions:
Before taking Zejula, patients should inform their doctors of any allergies, medical conditions, or medications they are taking. Patients with a history of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) should not take Zejula. Females who are pregnant or breastfeeding should not take Zejula.
Drug Interactions:
Zejula may interact with other medications, including over-the-counter and prescription drugs, herbal remedies, and supplements. Patients should inform their doctor of any medications they are taking or intend to take.
Contraindications:
Zejula should not be taken by patients who have a history of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Females who are pregnant or breastfeeding should not take Zejula.
Overdose:
Patients who take more than the prescribed dose of Zejula may experience adverse effects. Symptoms of an overdose may include nausea, vomiting, and decreased blood counts. Patients who suspect they have taken an overdose of Zejula should immediately contact their doctor.
Adverse Reactions:
The most common side effects of Zejula include nausea, vomiting, constipation, fatigue, and anemia. Other severe side effects may include hypertension, bone marrow suppression, and hypersensitivity to the drug. Patients should inform their doctor immediately if they experience any unusual symptoms while taking Zejula.
In summary, Zejula (niraparib) is an oral PARP inhibitor that is used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancers in adult patients. It works by blocking the activity of an enzyme called PARP and preventing cancer cells from repairing damaged DNA. Zejula should be stored at room temperature, and patients should take it orally once daily with or without food. Patients should inform their doctors of any allergies, medical conditions, or medications they are taking before taking Zejula. Females who are pregnant or breastfeeding should not take Zejula, and patients who have a history of MDS or AML should avoid it. Common side effects of Zejula may include nausea, vomiting, constipation, fatigue, and anemia.
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