Buy Zuvicin : Epirubicin 100 mg Injection Online

Description

Overview: Zuvicin is a medication manufactured by Zuventus Healthcare Ltd. containing the active substance Epirubicin. It is an anthracycline antineoplastic agent used in the treatment of various types of cancer, including breast cancer, gastric cancer, ovarian cancer, and soft tissue sarcomas. Zuvicin is administered intravenously and works by inhibiting DNA and RNA synthesis, thereby disrupting the growth and proliferation of cancer cells.

Active Substance:

• Epirubicin: Zuvicin contains Epirubicin, which is a semisynthetic derivative of doxorubicin, a commonly used anthracycline anticancer drug. Epirubicin exerts its cytotoxic effects by intercalating into DNA strands, inhibiting topoisomerase II enzyme activity, and inducing DNA strand breaks. This leads to inhibition of DNA and RNA synthesis, disruption of cell cycle progression, and ultimately, apoptosis (programmed cell death) in cancer cells.

Indications: Zuvicin (Epirubicin) 100 mg Injection is indicated for:

1. Breast Cancer: It is used in the treatment of early-stage or metastatic breast cancer, either as adjuvant therapy following surgery or in combination with other chemotherapy agents for advanced or metastatic disease.
2. Gastric Cancer: Zuvicin is indicated for the treatment of advanced or metastatic gastric cancer in combination with other chemotherapeutic agents.
3. Ovarian Cancer: It is used as part of combination chemotherapy regimens for the treatment of advanced or recurrent ovarian cancer.
4. Soft Tissue Sarcomas: Zuvicin is indicated for the treatment of soft tissue sarcomas, including liposarcoma, leiomyosarcoma, and malignant fibrous histiocytoma.

Mechanism of Action: Epirubicin exerts its antineoplastic effects by several mechanisms:

• Intercalation into DNA: Epirubicin intercalates into DNA strands, disrupting DNA structure and function, and inhibiting DNA replication and transcription.
• Inhibition of topoisomerase II: Epirubicin inhibits the activity of topoisomerase II enzyme, which is essential for DNA unwinding and replication. This leads to the formation of DNA strand breaks and interference with DNA repair mechanisms.
• Generation of free radicals: Epirubicin undergoes redox cycling in cells, leading to the formation of reactive oxygen species (ROS) and free radicals. These reactive species cause oxidative damage to cellular components and contribute to cytotoxicity and apoptosis in cancer cells.

Dosage and Administration: The dosage of Zuvicin (Epirubicin) 100 mg Injection is determined by the prescribing healthcare provider based on the patient’s body surface area, medical condition, and response to treatment. It is typically administered intravenously over a specified period of time, either as a single agent or as part of combination chemotherapy regimens. The injection should be given slowly into a vein, and proper precautions should be taken to minimize the risk of extravasation (leakage of medication into surrounding tissues).

Potential Side Effects: Common side effects associated with Zuvicin may include:

• Myelosuppression (decreased bone marrow function), leading to anemia, neutropenia, and thrombocytopenia
• Nausea, vomiting, or diarrhea
• Mucositis (inflammation of the mucous membranes)
• Alopecia (hair loss)
• Cardiotoxicity (damage to the heart muscle)
• Fatigue or weakness
• Injection site reactions
• Elevated liver enzymes

Precautions:

• Zuvicin should be used with caution in patients with preexisting cardiac disease, liver dysfunction, or bone marrow suppression.
• Patients should be monitored regularly for signs of adverse reactions, including hematological toxicity, cardiotoxicity, and hepatic dysfunction.
• Zuvicin may interact with other medications, including other chemotherapeutic agents and drugs that affect cardiac function or hepatic metabolism.

In conclusion, Zuvicin (Epirubicin) 100 mg Injection manufactured by Zuventus Healthcare Ltd. is used in the treatment of various types of cancer, including breast cancer, gastric cancer, ovarian cancer, and soft tissue sarcomas. By inhibiting DNA and RNA synthesis and inducing apoptosis in cancer cells, Epirubicin offers an effective treatment option for patients with advanced or metastatic disease. However, it may cause side effects and should be used under medical supervision.